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Fig. S6

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ZDB-IMAGE-180207-14
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Figures for Choi et al., 2018
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Fig. S6

Normal expressions of various neuronal markers in sam2cnu1 KO fish. (A) Alignment of human, mouse, and zebrafish Sam2 peptides. Putative amino acid sequences of mutant forms are also aligned. Dopaminergic neuron (th, B-B’; nurr1, C-C’; dat, L-L’), serotonergic neuron (tphR, D-D’; 5-HT, G-G’; pet-1, M-M’), oxytocinergic neuron (oxt, E-E’), and IPN (sst1, F-F’) markers. Additional neural markers: hcrt (H-H’), mch (I-I’), agrp (J-J’), and npy (K-K’). (N-O’) Normal hypothalamus (H) - locus coeruleus (LC) axonal connections in sam2cnu1 KO fish as judged by Tg[hcrt:EGFP] transgene expression. Dorsal views, anterior to the top. Scale bar, 100 μm. (P-R’) Serotonergic neuron (tphR, slc6a4a) and adrenocorticotropic hormone precursor pomc marker in adult brain. Arrowheads indicate the ventral posterior tuberculum (P-Q’) and the nucleus lateralis tuberis (R, R’). Bracket defines the raphe (P-Q’). (S-S’) c-fos expression in the novel tank assay. Scale bar, 500 μm.

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Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA