ZFIN ID: ZDB-GENE-990621-5
Gene Name: tyrosine hydroxylase
Gene Symbol: th
Sequence Ontology ID : SO:0000704

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Previous Name: th1 (1)

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
GENE EXPRESSION
All Expression Data: 229 figures from 106 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
  amacrine cell, amacrine cell dopaminergic neuron, anterior catecholaminergic tract, anterior commissure (all 108) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ion27Tg Transgenic Insertion Intron 12 Unknown DNA_AND_CRISPR
ion32Tg Transgenic Insertion Intron 12 Unknown DNA_AND_CRISPR
sa1635 Point Mutation Unknown Splice Site ENU
sa38085 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: CRISPR1-th (2), CRISPR2-th (1), CRISPR3-th (1), CRISPR4-th (1), CRISPR5-th (1) (all 12) expand
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in: behavioral fear response, dopamine biosynthetic process from tyrosine, multicellular organismal response to stress, whole organism
    DISEASE ASSOCIATED WITH th HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Segawa syndrome, recessive 605407
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dopamine biosynthetic process (more)
    Molecular Function tyrosine 3-monooxygenase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001273
  • InterPro:IPR005962
  • InterPro:IPR018301
  • InterPro:IPR019773
  • InterPro:IPR019774
  • InterPro:IPR021164
  • PROSITE:PS00367
  • PROSITE:PS51410
  • Pfam:PF00351
  • Pfam:PF12549
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000002329 (1) 1226
    th-001 (1) 1470
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-th (1), Ab2-th (1), Ab3-th (1), Ab4-th (1), Ab5-th (1) (all 8) expand
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM th
    Tg(-12th:GFP), tg(th:egfp), Tg(th:GAL4-VP16), Tg(th:GFP), tgbac(th:cre,myl7:cerulean)
    MARKER RELATIONSHIPS
    thContained in: [BAC] CH211-220G18 (1) (order this), IZAB-12K13
    thEncodes: [cDNA] MGC:194326 (1) (order this), MGC:194338 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131149 (1) 1470bp
    Genomic GenBank:AL954320 (1) 215130bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DJW5 489aa
    Sequence Clusters UniGene:88609 (1)
    Sequence Information (all 21)
    OTHER th GENE PAGES
  • Gene:30384 (1)
  • VEGA:OTTDARG00000002161 (1)
  • VEGA:OTTDARG00000013030 (1)
  • Ensembl(GRCz10):ENSDARG00000030621 (1)
  • ORTHOLOGY for th (Chr: 25)
    CITATIONS (179)