ZFIN ID: ZDB-GENE-990621-5
Gene Name: tyrosine hydroxylase
Gene Symbol: th

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Previous Name: th1 (1)

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(Including Attributions)
Location: Chr: 25 Mapping Details/Browsers
GENE EXPRESSION
All Expression Data: 224 figures from 102 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
  amacrine cell, amacrine cell dopaminergic neuron, anterior catecholaminergic tract, anterior commissure (all 108) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1635 Point Mutation Unknown Splice Site ENU
sa38085 Point Mutation Unknown Splice Site ENU
Targeting reagents: CRISPR1-th (2), CRISPR2-th (1), CRISPR3-th (1), CRISPR4-th (1), MO1-th (1) (all 11) expand
PHENOTYPE
Data: 3 figures from Formella et al., 2012
Observed in: behavioral fear response, dopamine biosynthetic process from tyrosine, multicellular organismal response to stress
DISEASE ASSOCIATED WITH th HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Segawa syndrome, recessive 605407
GENE ONTOLOGY
Ontology GO Term
Biological Process dopamine biosynthetic process (more)
Molecular Function tyrosine 3-monooxygenase activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001273 (1)
  • InterPro:IPR005962 (1)
  • InterPro:IPR018301 (1)
  • InterPro:IPR019773 (1)
  • InterPro:IPR019774 (1)
  • InterPro:IPR021164 (1)
  • PROSITE:PS00367 (1)
  • PROSITE:PS51410 (1)
  • Pfam:PF00351 (1)
  • Pfam:PF12549 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000002329 (1) 1226
    th-001 (1) 1470
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIES
    Ab1-th (1), Ab2-th (1), Ab3-th (1), Ab4-th (1), Ab5-th (1) (all 8) expand
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM th
    Tg(-12th:GFP), Tg(th:GAL4-VP16), Tg(th:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    thContained in: [BAC] CH211-220G18 (1) (order this), IZAB-12K13
    thEncodes: [cDNA] MGC:194326 (1) (order this), MGC:194338 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131149 (1) 1470bp
    Genomic GenBank:AL954320 (1) 215130bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DJW5 (1) 489aa
    Sequence Clusters UniGene:88609 (1)
    Sequence Information (all 21)
    OTHER th GENE PAGES
  • Gene:30384 (1)
  • VEGA:OTTDARG00000002161 (1)
  • VEGA:OTTDARG00000013030 (1)
  • Ensembl(GRCz10):ENSDARG00000030621 (1)
  • ORTHOLOGY for th (Chr: 25)
    Species Symbol Chromosome Accession # Evidence
    Human TH 11
  • Gene:7054
  • OMIM:191290
  • HGNC:11782
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Mouse Th 7
  • MGI:98735
  • Gene:21823
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (2)
    Download Curated Orthology
    CITATIONS (164)