ZFIN ID: ZDB-GENE-990621-5
Gene Name: tyrosine hydroxylase
Gene Symbol: th
Previous Name: th1 (1)
Location: Chr: 25   Details
GENE EXPRESSION
All Expression Data: 197 figures from 89 publications
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
  amacrine cell, amacrine cell dopaminergic neuron, anterior catecholaminergic tract, anterior commissure (all 87) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: CRISPR1-th (1), CRISPR2-th (1), MO1-th (1), MO2-th (1), MO3-th (1) (all 7) expand
PHENOTYPE
Data: 3 figures from Formella et al., 2012
Observed in: behavioral fear response, dopamine biosynthetic process from tyrosine, multicellular organismal response to stress

Phenotype of Human Orthologue OMIM Phenotype ID
Segawa syndrome, recessive 605407
GENE ONTOLOGY
Ontology GO Term
Biological Process dopamine biosynthetic process (more)
Molecular Function tyrosine 3-monooxygenase activity (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001273 (1)
  • InterPro:IPR005962 (1)
  • InterPro:IPR018301 (1)
  • InterPro:IPR019773 (1)
  • InterPro:IPR019774 (1)
  • InterPro:IPR021164 (1)
  • PROSITE:PS00367 (1)
  • PROSITE:PS51410 (1)
  • Pfam:PF00351 (1)
  • Pfam:PF12549 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ottdart00000002329 (1) 1226
    th-001 (1) 1470
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab2-th (1), Ab3-th (1), Ab4-th (1), Ab5-th (1), Ab6-th (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM th
    Tg(-12th:GFP), Tg(th:GAL4-VP16), Tg(th:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    th Contained in: [BAC] CH211-220G18 (1) (order this), IZAB-12K13
    th Encodes: [cDNA] MGC:194326 (1) (order this), MGC:194338 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131149 (1) 1470 bp
    Genomic GenBank:AL954320 (1) 215130 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B3DJW5 (1) 489 aa
    Sequence Clusters UniGene:88609 (1)
    Sequence Information (all 21)
    OTHER th GENE PAGES
  • Gene:30384 (1)
  • VEGA:OTTDARG00000002161 (1)
  • VEGA:OTTDARG00000013030 (1)
  • Ensembl(Zv9):ENSDARG00000030621 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish th 25  
    Human TH 11 (11p15.5)
  • OMIM:191290
  • Gene:7054
  • Mouse Th 7 ( 88.06 cM)
  • MGI:98735
  • Gene:21823
  • Orthology Details
    CITATIONS (134)