ZFIN ID: ZDB-GENE-990621-5
Gene Name: tyrosine hydroxylase
Gene Symbol: th    Nomenclature History

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Previous Name: th1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits tyrosine 3-monooxygenase activity. Involved in dopamine biosynthetic process and spinal cord motor neuron differentiation. Predicted to localize to axon; cytoplasm; and perikaryon. Is expressed in several structures, including chromaffin cell; digestive system; head; nervous system; and posterior presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase).
Genome Resources: Alliance (1),  Gene:30384 (1),  Ensembl(GRCz11):ENSDARG00000030621 (1)
GENE EXPRESSION
All Expression Data: 262 figures from 129 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ion27Tg Transgenic Insertion Intron 12 Unknown DNA_AND_CRISPR
ion32Tg Transgenic Insertion Intron 12 Unknown DNA_AND_CRISPR
sa1635 Point Mutation Unknown Splice Site ENU
sa38085 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf2193Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-th
    2
    CRISPR2-th
    1
    CRISPR3-th
    1
    CRISPR4-th
    1
    CRISPR5-th 1
    CRISPR6-th 1
    MO1-th N/A 1
    MO2-th N/A 4
    MO3-th N/A 1
    MO4-th N/A 2
    MO5-th N/A 2
    MO6-th N/A 1
    TALEN1-th 2
    TALEN2-th
    1
    DISEASE ASSOCIATED WITH th HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Segawa syndrome, recessive 605407
    DISEASE ASSOCIATED WITH th VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process catecholamine biosynthetic process (more)
    Cellular Component axon (more)
    Molecular Function tyrosine 3-monooxygenase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ottdart00000002329 (1) 1226
    th-201 (1)    Ensembl 1470
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    ab8-th Rabbit WB 1
    ab7-th IgY Chicken IHC, WB 2
    Ab5-th monoclonal IgG2a , k Mouse IHC Vector Laboratories
    3
    Ab3-th monoclonal IgG1 , k Mouse IHC, WB Millipore
    Antibodies-online.com
    97
    Ab4-th polyclonal Rabbit IHC, WB Millipore
    27
    Ab1-th monoclonal IgG1 Mouse IHC, WB ImmunoStar, Inc.
    34
    Ab2-th polyclonal Rabbit IHC Pel-Freez Biologicals
    10
    Ab6-th polyclonal Rabbit IHC 15
    CONSTRUCTS WITH SEQUENCES FROM th
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-12th:GFP) th GFP Danio rerio 1 4
    Tg(th:EGFP) th EGFP Danio rerio 0 1
    Tg(th:GAL4-VP16) th GAL4VP16 Danio rerio 1 5
    Tg(th:GFP) th GFP Danio rerio 1 2
    TgBAC(th:Cre,myl7:Cerulean) myl7th CeruleanCre Danio rerio 1 1
    MARKER RELATIONSHIPS
    th Contained in: [BAC] CH211-220G18 (1), IZAB-12K13
    th Encodes: [cDNA] MGC:194326 (1), MGC:194338 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131149 (1) 1470 nt
    Genomic GenBank:AL954320 (1) 215130 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8RPJ0 (1) 505 aa
    Sequence Information (all 21)
    ORTHOLOGY for th ( Chr: 25 )
    CITATIONS (233)