ZFIN ID: ZDB-GENE-990415-184
Gene Name: nuclear receptor subfamily 4, group A, member 2a
Gene Symbol: nr4a2a    Nomenclature History

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Previous Name: nurr1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II proximal promoter sequence-specific DNA binding activity and glucocorticoid receptor binding activity. Involved in dopaminergic neuron differentiation; forebrain neuron development; and neutrophil homeostasis. Predicted to localize to the nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in brain; dopaminergic neurons; and retina. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2).
Genome Resources: Alliance (1),  Gene:100008101 (1),  Ensembl(GRCz11):ENSDARG00000017007 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-nr4a2a,nr4a2b N/A 1
MO2-nr4a2a N/A 2
MO2-nr4a2a,nr4a2b N/A 4
DISEASE ASSOCIATED WITH nr4a2a HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH nr4a2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process central nervous system neuron differentiation (more)
Cellular Component integral component of membrane (more)
Molecular Function DNA binding (more)
GO Terms (all 21)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003070 Orphan nuclear receptor
Family IPR003073 Orphan nuclear receptor, NURR type
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nr4a2a-202 (1)    Ensembl 2153
ncRNA nr4a2a-002 (1)    Ensembl 496
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nr4a2a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(nr4a2a:EGFP) nr4a2a EGFP Danio rerio 1 1
MARKER RELATIONSHIPS
nr4a2a Contained in: [BAC] RP71-49K16 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001113484 (1) 1797 nt
Genomic GenBank:CU179638 (1) 137047 nt
Select Tool
Polypeptide UniProtKB:F1RER4 (1) 635 aa
Sequence Information (all 15)
ORTHOLOGY for nr4a2a ( Chr: 9 )
CITATIONS (35)