ZFIN ID: ZDB-GENE-030407-1
Gene Name: oxytocin
Gene Symbol: oxt    Nomenclature History

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Previous Names: fj33a01, isotocin neurophysin (1), IT-NP (1), itnp, oxtl (1), wu:fj33a01 (1), wu:fq40d10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have neuropeptide hormone activity. Involved in ion homeostasis. Predicted to localize to the extracellular space and secretory granule. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Orthologous to human OXT (oxytocin/neurophysin I prepropeptide).
Genome Resources: Alliance (1),  Gene:352920 (1),  Ensembl(GRCz11):ENSDARG00000042845 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20598 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33779 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • wz13 Small Deletion Exon 2 Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-oxt 3
    CRISPR2-oxt
    1
    CRISPR3-oxt
    1
    CRISPR4-oxt
    1
    CRISPR5-oxt
    1
    CRISPR6-oxt
    1
    CRISPR7-oxt
    1
    CRISPR9-oxt
    1
    CRISPR10-oxt
    1
    MO1-oxt N/A 1
    MO2-oxt N/A 2
    MO8-oxt N/A 1
    DISEASE ASSOCIATED WITH oxt HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH oxt VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion homeostasis (more)
    Cellular Component extracellular region (more)
    Molecular Function neurohypophyseal hormone activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR022423 Neurohypophysial hormone, conserved site
    Family IPR000981 Neurohypophysial hormone
    Homologous_superfamily IPR036387 Neurohypophysial hormone domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-oxt polyclonal Guinea pig IHC Bachem
    3
    Ab3-oxt polyclonal Rabbit IHC 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM oxt
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(oxt:EGFP) oxt EGFP Danio rerio 1 9
    tg(oxt:egfp-utr-oxt) oxt EGFPoxtUTR Danio rerio 1 1
    Tg(oxt:GAL4-VP16,myl7:EGFP) myl7oxt EGFPGAL4VP16 Danio rerio 1 3
    Tg(oxt:LOX2272-LOXP-MA-RFP-LOX2272-MA-YFP-LOXP-MA-CFP) oxt CFPLOX2272LOXPMARFPYFP Danio rerio 1 1
    Tg(oxt:oxtSP-EGFP-oxt,myl7:EGFP) myl7oxt EGFPoxt Danio rerio 1 3
    Tg2(oxt:EGFP) oxt EGFP Danio rerio 3 5
    Tg3(oxt:EGFP) oxt EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    oxt Encodes: [EST] fj33a01 (1), fq40d10 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_178291 (1)
    Genomic GenBank:CABZ01087673 (1) 4329 nt
    Polypeptide UniProtKB:F1QC27 (1) 154 aa
    Sequence Information (all 11)
    ORTHOLOGY for oxt ( Chr: 5 )
    CITATIONS (75)