ZFIN ID: ZDB-GENE-010316-1
Gene Name: solute carrier family 6 member 3
Gene Symbol: slc6a3    Nomenclature History

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Previous Names: DAT (1), dat (1), dopamine transporter (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have neurotransmitter:sodium symporter activity. Predicted to localize to integral component of membrane. Is expressed in several structures, including dopaminergic neurons; forebrain; male organism; medulla oblongata; and retina. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3).
Genome Resources: Alliance (1),  Gene:80787 (1),  Ensembl(GRCz11):ENSDARG00000004219 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
f8 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
zf1089 Insertion Exon 12 Frameshift ZINC_FINGER_NUCLEASE
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-slc6a3
1
CRISPR2-slc6a3
2
CRISPR3-slc6a3
1
MO1-slc6a3 N/A 1
TALEN1-slc6a3
2
PHENOTYPE
Data: 6 figures from 3 publications
Observed in:
DISEASE ASSOCIATED WITH slc6a3 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Parkinsonism-dystonia, infantile, 1 613135
{Nicotine dependence, protection against} 188890
DISEASE ASSOCIATED WITH slc6a3 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process dopamine uptake involved in synaptic transmission (more)
Cellular Component integral component of membrane (more)
Molecular Function neurotransmitter:sodium symporter activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM slc6a3
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(-7slc6a3:EGFP) slc6a3 EGFP Danio rerio 1 2
Tg(-7slc6a3:mRFP) slc6a3 mRFP Danio rerio 2 2
Tg(-11slc6a3:EGFP) slc6a3 EGFP Danio rerio 2 3
Tg(slc6a3:CFP-NTR) slc6a3 CFPNTR Danio rerio 1 1
Tg(slc6a3:Cr.ChR2-ECFP) slc6a3 ECFP Chlamydomonas reinhaDanio rerio 1 1
Tg(slc6a3:EGFP) slc6a3 EGFP Danio rerio 1 16
Tg(slc6a3:GAL4-VP16) slc6a3 GAL4VP16 Danio rerio 1 2
Tg(slc6a3:MITO-mCherry-NPT) slc6a3 mCherryMITONPT Danio rerio 1 2
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131755 (1) 1890 nt
Polypeptide UniProtKB:F1QGM4 (1) 629 aa
Sequence Information (all 7)
ORTHOLOGY for slc6a3 ( Chr: 16 )
CITATIONS (106)