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ZIRC
ZFIN ID: ZDB-GENE-040624-4
Gene Name: tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
Gene Symbol: tph2    Nomenclature History

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Previous Names: tph2a (1), tphR (1), wu:fq15a04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have tryptophan 5-monooxygenase activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to the neuron projection. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; major depressive disorder; and panic disorder. Is expressed in brain and neurons. Orthologous to human TPH2 (tryptophan hydroxylase 2).
Genome Resources: Alliance (1),  Gene:407712 (1),  Ensembl(GRCz11):ENSDARG00000057239 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct817 Indel Unknown Unknown ZINC_FINGER_NUCLEASE
ion39Tg Transgenic Insertion Intron 9 Unknown DNA_AND_CRISPR
sa8576 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tph2 1
    MO2-tph2 N/A 1
    DISEASE ASSOCIATED WITH tph2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    endogenous depression Alliance {Unipolar depression, susceptibility to} 608516
    {Attention deficit-hyperactivity disorder, susceptibility to, 7} 613003
    DISEASE ASSOCIATED WITH tph2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of hematopoietic stem cell differentiation (more)
    Cellular Component neuron projection (more)
    Molecular Function iron ion binding (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tph2-201 (1)    Ensembl 2010
    tph2-202 (1)    Ensembl 2216
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tph2 monoclonal IgG2a Rat IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tph2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(tph2:chr2-yfp) tph2 ChR2YFP Danio rerio 1 1
    Tg(tph2:Eco.NfsB-mCherry) tph2 mCherry Danio rerioEscherichia coli 4 9
    tg(tph2:egfp) tph2 EGFP Danio rerio 1 1
    tg(tph2:entr-yfp) tph2 NTRYFP Danio rerio 1 1
    Tg(tph2:epNTR-TagRFPT) tph2 NTRTagRFPT Danio rerio 1 2
    Tg(tph2:GAL4FF) tph2 GAL4FF Danio rerio 8 12
    MARKER RELATIONSHIPS
    tph2 Contained in: [BAC] CH211-218C6 (1) (order this)
    tph2 Encodes: [EST] fq15a04 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_214795 (1) 2188 bp
    Genomic GenBank:BX950194 (1) 122061 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4ILE6 (1) 500 aa
    Sequence Clusters UniGene:84644 (1)
    Sequence Information (all 21)
    ORTHOLOGY for tph2 ( Chr: 18 )
    CITATIONS (60)