ZFIN ID: ZDB-GENE-040624-4
Gene Name: tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
Gene Symbol: tph2
Sequence Ontology ID : SO:0000704

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Previous Names: tph2a (1), tphR (1), wu:fq15a04

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(Including Attributions)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have tryptophan 5-monooxygenase activity; involved in regulation of hematopoietic stem cell differentiation; predicted to localize to the neuron projection; orthologous to human TPH2  ...
GENE EXPRESSION
All Expression Data: 28 figures from 21 publications
Directly Submitted Expression Data: 4 figures (15 images) from Rauch et al., 2003 [fq15a04]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct817 Indel Unknown Unknown ZINC_FINGER_NUCLEASE
ion39Tg Transgenic Insertion Intron 9 Unknown DNA_AND_CRISPR
sa8576 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 2 figures from Kwan et al., 2016
    Observed in:
    DISEASE ASSOCIATED WITH tph2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    endogenous depression {Unipolar depression, susceptibility to} 608516
    {Attention deficit-hyperactivity disorder, susceptibility to, 7} 613003
    DISEASE ASSOCIATED WITH tph2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of hematopoietic stem cell differentiation (more)
    Cellular Component cellular_component (more)
    Molecular Function iron ion binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001273 (1)
  • InterPro:IPR002912 (1)
  • InterPro:IPR005963 (1)
  • InterPro:IPR018301 (1)
  • InterPro:IPR019773 (1)
  • InterPro:IPR019774 (1)
  • InterPro:IPR036329 (1)
  • InterPro:IPR036951 (1)
  • PROSITE:PS00367 (1)
  • PROSITE:PS51410 (1)
  • PROSITE:PS51671 (1)
  • Pfam:PF00351 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tph2-001 (1) 2216
    tph2-002 (1) 2010
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tph2
    MARKER RELATIONSHIPS
    tph2Contained in: [BAC] CH211-218C6 (1) (order this)
    tph2Encodes: [EST] fq15a04 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_214795 (1) 2188bp
    Genomic GenBank:BX950194 (1) 122061bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4ILE6 (1) 500aa
    Sequence Clusters UniGene:84644 (1)
    Sequence Information (all 21)
    OTHER tph2 GENE PAGES
  • Alliance (1)
  • Gene:407712 (1)
  • VEGA:OTTDARG00000012840 (1)
  • ORTHOLOGY for tph2 (Chr: 18)
    CITATIONS (55)