Gene
ctslb
- ID
- ZDB-GENE-980526-285
- Name
- cathepsin Lb
- Symbol
- ctslb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Localizes to extracellular region. Is expressed in several structures, including ectoderm; hatching gland; hatching gland cell; hypoblast; and mesoderm. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L).
- Genome Resources
- Note
-
This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.
- Comparative Information
-
- All Expression Data
- 166 figures from 111 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb15 (8 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
Active_site | IPR025660 | Cysteine peptidase, histidine active site |
Active_site | IPR025661 | Cysteine peptidase, asparagine active site |
Domain | IPR000668 | Peptidase C1A, papain C-terminal |
Domain | IPR013201 | Cathepsin propeptide inhibitor domain (I29) |
Domain | IPR039417 | Papain-like cysteine endopeptidase |
Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
Protein | Length | Cathepsin propeptide inhibitor domain (I29) | Cysteine peptidase, asparagine active site | Cysteine peptidase, cysteine active site | Cysteine peptidase, histidine active site | Papain-like cysteine endopeptidase | Papain-like cysteine peptidase superfamily | Peptidase C1A, papain C-terminal |
---|---|---|---|---|---|---|---|---|
UniProtKB:A8E587
|
336 | |||||||
UniProtKB:A7MCM3
|
335 | |||||||
UniProtKB:A7MCR7
|
336 | |||||||
UniProtKB:Q32PQ1
|
336 | |||||||
UniProtKB:P79722
|
336 | |||||||
UniProtKB:F1R7B3
|
352 | |||||||
UniProtKB:R4GEZ3
|
66 | |||||||
UniProtKB:A0A2R8Q790
|
336 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
ctslb-201
(1)
|
1351 nt | |
mRNA |
ctslb-203
(1)
|
1289 nt | |
mRNA |
si:dkey-26g8.4-201
(1)
|
1348 nt | |
mRNA |
si:dkey-26g8.4-202
(1)
|
308 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance