ZFIN ID: ZDB-GENE-980526-285
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Gene Name: cathepsin Lb
Gene Symbol: ctslb
Sequence Ontology ID : SO:0000704

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Previous Names: catL, cstlb (1), ctsl1b, ctsl, cathepsin L, cb15 (1), hatching gland 1 (1), hgg1 (1), wu:fb30g09 (1)

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(Including Attributions)
Location: Chr: 12 Mapping Details/Browsers
Nomenclature History
Note: This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.
AUTOMATED DESCRIPTION
Predicted to have cysteine-type endopeptidase activity; predicted to be involved in proteolysis involved in cellular protein catabolic process; localizes to the extracellular region; orthologous to  ...
GENE EXPRESSION
All Expression Data: 150 figures from 100 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2001 [cb15]
  11 figures (28 images) from Rauch et al., 2003 [fc13c06]
Wild-type Stages, Structures: Blastula:128-cell (2.25h-2.5h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22068 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa27926 Point Mutation Unknown Premature Stop ENU
    sa44754 Point Mutation Unknown Unknown ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ctslb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ctslb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular region (more)
    Molecular Function cysteine-type peptidase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000169 (1)
  • InterPro:IPR000668 (1)
  • InterPro:IPR013128 (1)
  • InterPro:IPR013201 (1)
  • InterPro:IPR025660 (1)
  • InterPro:IPR025661 (1)
  • InterPro:IPR038765 (1)
  • InterPro:IPR039417 (1)
    		•
  • PROSITE:PS00139 (1)
  • PROSITE:PS00639 (1)
  • PROSITE:PS00640 (1)
    		•
  • Pfam:PF00112 (1)
  • Pfam:PF08246 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ctslb-201 (1) 1351
    Select Tool
    ctslb-203 (1) 1289
    Select Tool
    si:dkey-26g8.4-201 (1) 1348
    Select Tool
    si:dkey-26g8.4-202 (1) 308
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ctslb No data available
    MARKER RELATIONSHIPS
    ctslbContained in: [BAC] DKEY-239J18 (1) (order this), DKEY-269I1 (1) (order this)
    ctslbEncodes: [EST] cb15 (1) (order this), fb30g09 (1), fc13c06 (1) (order this)
    [cDNA] MGC:123162 (1) (order this), MGC:174152 (1) (order this), MGC:174155 (1) (order this), MGC:174856 (1) (order this), MGC:174857 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA GenBank:BC108031 (1) 1320bp
    Select Tool
    Genomic GenBank:BX322603 (1) 191741bp
    Select Tool
    Polypeptide UniProtKB:F1R7B3 (1) 352aa
    Select Tool
    Sequence Information (all 22)
    OTHER ctslb GENE PAGES
  • Alliance (1)
  • VEGA:OTTDARG00000020540 (1)
  • VEGA:OTTDARG00000040457 (1)
  • VEGA:OTTDARG00000040458 (1)
  • Ensembl(GRCz11):ENSDARG00000074306 (1)
    • ORTHOLOGY for ctslb (Chr: 12)
    CITATIONS (207)