ZFIN ID: ZDB-GENE-980526-285
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: cathepsin Lb
Gene Symbol: ctslb    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: catL, cstlb (1), ctsl1b, ctsl, cathepsin L, cb15 (1), hatching gland 1 (1), hgg1 (1), wu:fb30g09 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Localizes to the extracellular region. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Is expressed in several structures, including ectoderm; hatching gland; hatching gland cell; hypoblast; and mesoderm. Orthologous to several human genes including CTSL (cathepsin L).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000074306 (1)
Note: This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.
GENE EXPRESSION
All Expression Data: 153 figures from 103 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2001 [cb15]
  11 figures (28 images) from Rauch et al., 2003 [fc13c06]
Wild-type Stages, Structures: Blastula:128-cell (2.25h-2.5h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22068 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa27926 Point Mutation Unknown Premature Stop ENU
    sa44754 Point Mutation Unknown Unknown ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ctslb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ctslb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component extracellular region (more)
    Molecular Function cysteine-type peptidase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR000169 Cysteine peptidase, cysteine active site
    Active_site IPR025660 Cysteine peptidase, histidine active site
    Active_site IPR025661 Cysteine peptidase, asparagine active site
    Domain IPR000668 Peptidase C1A, papain C-terminal
    Domain IPR013201 Cathepsin propeptide inhibitor domain (I29)
    Domain IPR039417 Papain-like cysteine endopeptidase
    Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctslb-201 (1)    Ensembl 1351
    Select Tool
    ctslb-203 (1)    Ensembl 1289
    Select Tool
    si:dkey-26g8.4-201 (1)    Ensembl 1348
    Select Tool
    si:dkey-26g8.4-202 (1)    Ensembl 308
    Select Tool
    Browsers: Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ctslb polyclonal IgG Rabbit WB GeneTex
    		1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctslb No data available
    MARKER RELATIONSHIPS
    ctslb Contained in: [BAC] DKEY-239J18 (1) (order this), DKEY-269I1 (1) (order this)
    ctslb Encodes: [EST] cb15 (1) (order this), fb30g09 (1), fc13c06 (1) (order this)
    [cDNA] MGC:123162 (1), MGC:174152 (1), MGC:174155 (1), MGC:174856 (1), MGC:174857 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:BC108031 (1) 1320 nt
    Select Tool
    Genomic GenBank:BX322603 (1) 191741 nt
    Select Tool
    Polypeptide UniProtKB:F1R7B3 (1) 352 aa
    Select Tool
    Sequence Information (all 22)
    ORTHOLOGY for ctslb ( Chr: 12 )
    CITATIONS (214)