Gene

ctslb

ID
ZDB-GENE-980526-285
Name
cathepsin Lb
Symbol
ctslb Nomenclature History
Previous Names
  • catL
  • cstlb (1)
  • ctsl1b
  • ctsl
  • cathepsin L
  • cb15 (1)
  • hatching gland 1 (1)
  • hgg1 (1)
  • wu:fb30g09 (1)
Type
protein_coding_gene
Location
Chr: 12 Mapping Details/Browsers
Description
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Predicted to act upstream of or within proteolysis. Located in extracellular region. Is expressed in several structures, including hatching gland; hatching gland cell; hypoblast; mesoderm; and swim bladder. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to several human genes including CTSL (cathepsin L).
Genome Resources
Note
This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl.
Comparative Information
Expression
All Expression Data
164 figures from 109 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctslb Human Ortholog
No data available
Associated With ctslb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR000169 Cysteine peptidase, cysteine active site
Active_site IPR025660 Cysteine peptidase, histidine active site
Active_site IPR025661 Cysteine peptidase, asparagine active site
Domain IPR000668 Peptidase C1A, papain C-terminal
Domain IPR013201 Cathepsin propeptide inhibitor domain (I29)
Domain IPR039417 Papain-like cysteine endopeptidase
Homologous_superfamily IPR038765 Papain-like cysteine peptidase superfamily
Domain Details Per Protein
Protein Length Cathepsin propeptide inhibitor domain (I29) Cysteine peptidase, asparagine active site Cysteine peptidase, cysteine active site Cysteine peptidase, histidine active site Papain-like cysteine endopeptidase Papain-like cysteine peptidase superfamily Peptidase C1A, papain C-terminal
UniProtKB:A0A2R8Q790 336
UniProtKB:A7MCM3 335
UniProtKB:P79722 336
UniProtKB:A7MCR7 336
UniProtKB:A8E587 336
UniProtKB:A7MCR8 335
UniProtKB:R4GEZ3 66
UniProtKB:Q32PQ1 336
UniProtKB:F1R7B3 352
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ctslb polyclonal IgG Rabbit
  • WB
GeneTex
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations