| ZFIN ID: ZDB-GENE-980526-285 |
| Gene Name: | cathepsin Lb | |||||||||||||
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| Gene Symbol: | ctslb Nomenclature History |
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Attributions
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| Previous Names: | catL, cstlb (1), ctsl1b, ctsl, cathepsin L, cb15 (1), hatching gland 1 (1), hgg1 (1), wu:fb30g09 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 12 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Localizes to the extracellular region. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Is expressed in several structures, including ectoderm; hatching gland; hatching gland cell; hypoblast; and mesoderm. Orthologous to several human genes including CTSL (cathepsin L). | |||||||||||||
| Genome Resources: | Alliance (1), Ensembl(GRCz11):ENSDARG00000074306 (1) | |||||||||||||
| Note: | This sequence is in a cluster of genes on chromosome 12 that may or may not be tandem duplicates of cstl. | |||||||||||||
| All Expression Data: | 152 figures from 102 publications |
| Directly Submitted Expression Data: | 6 figures (8 images) from Thisse et al., 2001 [cb15] |
| 11 figures (28 images) from Rauch et al., 2003 [fc13c06] | |
| Wild-type Stages, Structures: | Blastula:128-cell (2.25h-2.5h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) |
| Curated Microarray Expression: | GEO (1) |
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa22068 | Point Mutation | Unknown | Splice Site | ENU |
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| sa27926 | Point Mutation | Unknown | Premature Stop | ENU | |
| sa44754 | Point Mutation | Unknown | Unknown | ENU |
| Ontology | GO Term |
|---|---|
| Biological Process | proteolysis (more) |
| Cellular Component | extracellular region (more) |
| Molecular Function | cysteine-type peptidase activity (more) |
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| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
ctslb-201
(1)
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1351 |
Select Tool
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ctslb-203
(1)
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1289 |
Select Tool
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si:dkey-26g8.4-201
(1)
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1348 |
Select Tool
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si:dkey-26g8.4-202
(1)
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308 |
Select Tool
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| Browsers: Ensembl, ZFIN |
| Name | Type | Isotype | Host Organism | Assay | Source | Publications |
|---|---|---|---|---|---|---|
| Ab1-ctslb | polyclonal | IgG | Rabbit | WB |
GeneTex
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1 |
| ctslb Contained in: | [BAC] DKEY-239J18 (1) (order this), DKEY-269I1 (1) (order this) |
| ctslb Encodes: |
[EST]
cb15 (1) (order this),
fb30g09 (1),
fc13c06 (1) (order this)
[cDNA] MGC:123162 (1) (order this), MGC:174152 (1) (order this), MGC:174155 (1) (order this), MGC:174856 (1) (order this), MGC:174857 (1) (order this) |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | GenBank:BC108031 (1) | 1320 bp |
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| Genomic | GenBank:BX322603 (1) | 191741 bp | |
| Polypeptide | UniProtKB:F1R7B3 (1) | 352 aa |
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