ZFIN ID: ZDB-GENE-040426-2706
Gene Name: serine and arginine rich splicing factor 2a
Gene Symbol: srsf2a    Nomenclature History

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Previous Names: sfrs2, srsf2, hm:zeh0252, wu:fb51a05, wu:fk59b08, zgc:56283

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have RNA binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to the cytoplasm and nuclear speck. Human ortholog(s) of this gene implicated in acute myeloid leukemia and myelodysplastic syndrome. Orthologous to several human genes including SRSF2 (serine and arginine rich splicing factor 2).
Genome Resources: Alliance (1),  Gene:406691 (1),  Ensembl(GRCz11):ENSDARG00000057484 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56283]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012192Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35331 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH srsf2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH srsf2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of alternative mRNA splicing, via spliceosome (more)
    Cellular Component cytoplasm (more)
    Molecular Function nucleic acid binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000504 RNA recognition motif domain
    Domain IPR003954 RNA recognition motif domain, eukaryote
    Family IPR034893 Serine/arginine-rich splicing factor 2-like
    Homologous_superfamily IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
    Homologous_superfamily IPR035979 RNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript srsf2a-202 (1)    Ensembl 582
    srsf2a-205 (1)    Ensembl 567
    srsf2a-206 (1)    Ensembl 603
    srsf2a-208 (1)    Ensembl 908
    mRNA srsf2a-201 (1)    Ensembl 1776
    srsf2a-204 (1)    Ensembl 1151
    srsf2a-207 (1)    Ensembl 855
    srsf2a-209 (1)    Ensembl 707
    ncRNA srsf2a-002 (1)    Ensembl 1024
    srsf2a-010 (1)    Ensembl 636
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM srsf2a No data available
    MARKER RELATIONSHIPS
    srsf2a Contained in: [BAC] CH211-134H7 (1)
    srsf2a Contains: [SNP] rs3728510 (1), rs3728511 (1)
    srsf2a Encodes: [EST] fb51a05, fk59b08, zeh0252
    [cDNA] MGC:56283 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213382 (1) 1796 nt
    Genomic GenBank:CR352342 (1) 186937 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZV13 (1) 225 aa
    Sequence Information (all 20)
    ORTHOLOGY for srsf2a ( Chr: 12 )
    CITATIONS (27)