ZFIN ID: ZDB-GENE-000201-18
Gene Name: pre-B-cell leukemia transcription factor 4
Gene Symbol: pbx4    Nomenclature History

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Previous Names: pbxx, fb77e11, lazarus (1), lzr, wu:fb77e11 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including animal organ development; generation of neurons; and regulation of histone modification. Localizes to nucleus. Orthologous to human PBX4 (PBX homeobox 4).
Genome Resources: Alliance (1),  Gene:30728 (1),  Ensembl(GRCz11):ENSDARG00000052150 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7152524]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b557 Point Mutation Unknown Premature Stop
hi933Tg Transgenic Insertion Intron 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi1126Tg Transgenic Insertion Unknown Unknown DNA
    la028943Tg Transgenic Insertion Unknown Unknown DNA
    la028944Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • scm14 Point Mutation Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-pbx4 1
    CRISPR2-pbx4
    1
    CRISPR3-pbx4
    1
    MO1-pbx4 N/A 2
    MO2-pbx4 N/A 11
    MO3-pbx4 N/A 9
    MO4-pbx4 N/A 1
    MO5-pbx4 N/A 1
    DISEASE ASSOCIATED WITH pbx4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pbx4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 32)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pbx4-201 (1)    Ensembl 4379
    pbx4-202 (1)    Ensembl 827
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pbx polyclonal Rabbit WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pbx4 No data available
    MARKER RELATIONSHIPS
    pbx4 Contained in: [BAC] DKEY-189E16 (1) (order this)
    pbx4 Encodes: [EST] fb77e11 (1), IMAGE:7152524 (1)
    [cDNA] MGC:193543 (1), MGC:193573 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131447 (1) 2854 nt
    Genomic GenBank:CU302192 (1) 159807 nt
    Select Tool
    Polypeptide UniProtKB:Q9PW77 (1) 343 aa
    Sequence Information (all 21)
    ORTHOLOGY for pbx4 ( Chr: 3 )
    CITATIONS (64)