ZFIN ID: ZDB-GENE-070424-11
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Gene Name: pre-B-cell leukemia homeobox 1b
Gene Symbol: pbx1b    Nomenclature History

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Previous Name: zgc:158824

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Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in precursor B lymphoblastic lymphoma/leukemia. Is expressed in head. Orthologous to human PBX1 (PBX homeobox 1).
Genome Resources: Alliance (1),  Gene:570960 (1),  Ensembl(GRCz11):ENSDARG00000101131 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa15193 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa26652 Point Mutation Unknown Premature Stop ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pbx1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay 617641
    DISEASE ASSOCIATED WITH pbx1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001356 Homeobox domain
    Domain IPR005542 PBX
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Conserved_site IPR017970 Homeobox, conserved site
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pbx polyclonal Rabbit WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pbx1b No data available
    MARKER RELATIONSHIPS
    pbx1b Encodes: [cDNA] MGC:158824 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001083853 (1) 2069 bp
    Select Tool
    Genomic GenBank:FO834865 (1) 96458 bp
    Select Tool
    Polypeptide UniProtKB:A2VD48 (1) 429 aa
    Select Tool
    Sequence Information (all 20)
    ORTHOLOGY for pbx1b ( Chr: 6 )
    CITATIONS (18)