Gene
pbx1b
- ID
- ZDB-GENE-070424-11
- Name
- pre-B-cell leukemia homeobox 1b
- Symbol
- pbx1b Nomenclature History
- Previous Names
-
- zgc:158824
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to be involved in several processes, including embryonic organ development; eye development; and nervous system development. Predicted to be located in nucleus. Predicted to be part of transcription regulator complex. Is expressed in head. Human ortholog(s) of this gene implicated in congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay. Orthologous to human PBX1 (PBX homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay | Alliance | Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay | 617641 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | KN homeodomain | PBX, PBC domain | Three Amino acid Loop Extension (TALE) homeobox |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PM87 | InterPro | 346 | ||||||
| UniProtKB:A2VD48 | InterPro | 429 | ||||||
| UniProtKB:F1QSY5 | InterPro | 429 | ||||||
| UniProtKB:A0A8M9QFI5 | InterPro | 433 | ||||||
| UniProtKB:A0A8M9QAG1 | InterPro | 350 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available