FIGURE

Fig. 3

ID

ZDB-FIG-221226-307

Publication

Saettele et al., 2022 - Prolonged Dexamethasone Exposure Enhances Zebrafish Lateral-Line Regeneration But Disrupts Mitochondrial Homeostasis and Hair Cell Function

Other Figures

All Figure Page

Back to All Figure Page

Fig. 3

Dexamethasone-enhanced afferent innervation of regenerating neuromasts. A–D Representative maximum intensity projection images of pLL neuromasts in 7 dpf tgBAC (neurod1: GFP) larvae showing afferent neurons (green) and DAPI-labeled hair cell nuclei (blue). Neuromasts were either unlesioned (A, B) or lesioned with CuSO₄ (C, D), then allowed to regenerate for 48 h while exposed to DMSO (carrier) (A, C) or dexamethasone (B, D). E, F Box plots of neurite length per neuromast (E) and neurite length per hair cell (F), with whiskers at min/max and mean values marked with “ + ”. Data for each experimental trial were normalized to the median value of unlesioned controls. Regenerating neuromasts (orange plots) in dexamethasone-treated fish had significantly longer neurites per neuromast (E) (****adjusted P < 0.0001); however, the difference in length in dexamethasone-treated fish was not significant relative to the total number of hair cells/neuromast, when compared to DMSO controls (F). N = 4–7 fish per condition per trial; 6 experimental trials

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Assoc. Res. Otolaryngol.