FIGURE

Fig. 2

ID

ZDB-FIG-221226-306

Publication

Saettele et al., 2022 - Prolonged Dexamethasone Exposure Enhances Zebrafish Lateral-Line Regeneration But Disrupts Mitochondrial Homeostasis and Hair Cell Function

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Fig. 2

Dexamethasone increased hair cell number in intact and regenerating neuromasts. A–D Representative maximum intensity projection images of 7 dpf neuromasts, with DAPI-labeled hair cell nuclei (blue). Larval lateral-line neuromasts were either left intact (unlesioned) (A, B) or lesioned by treatment with 3 µM CuSO₄ for 1 h (C, D). Larvae were then allowed to recover for 2 h, then exposed for 48 h to either 0.1 % DMSO (carrier) (A, C) or dexamethasone (B, D). E Scatter plot graph of hair cell number per neuromast. Bars indicate mean and SEM. Each dot represents a single neuromast on an individual fish. Both intact (unlesioned) and regenerating neuromasts showed a significant increase in the number of hair cells per neuromast in dexamethasone-treated fish relative to DMSO controls (****adjusted P < 0.0001;). N = 5–10 fish per condition per trial; 7 experimental trials

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Assoc. Res. Otolaryngol.