FIGURE

Fig. 8

ID

ZDB-FIG-220622-33

Publication

Fleming et al., 2022 - Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency

Other Figures

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Fig. 8

FIGURE 8. Imaging of lysosomes. In vivo lysotracker staining was imaged using confocal microscopy. (A) A striking increase in lysotracker staining was observed in the spinal cord of sumf1^−/− larvae compared to wildtype (wt) larvae at 2 d.p.f., 5 d.p.f., and 10 d.p.f. (B) An increase in lysotracker staining was observed in and around the otic vesicle of sumf1^−/− larvae compared to wt larvae at 5 d.p.f., whereas no differences between the two groups were observed at 10 d.p.f. (A–C) Representative images of the lysotracker staining, brightfield and the z projection. At least 5 fish were analysed for each group. Scale bar represents 30 µm for all images.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sumf1^{la015919Tg/la015919Tg} (TL)
Observed In:	otic vesicle lysosome spinal cord lysosome
Stage Range:	Long-pec to Days 7-13

Phenotype Detail

Acknowledgments

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