FIGURE

Fig. 3

ID

ZDB-FIG-220622-28

Publication

Fleming et al., 2022 - Unexpected Phenotype Reversion and Survival in a Zebrafish Model of Multiple Sulfatase Deficiency

Other Figures

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Fig. 3

FIGURE 3. Intercalation of chondrocytes in the craniofacial skeleton. Alcian blue stained samples of (A,B) wildtype (n = 4) and (D,E) sumf1^−/− zebrafish (n = 6) at 5 d.p.f. The chondrocytes of wildtype larvae (B) at 5 d.p.f. were neatly stacked (asterisk) indicating complete intercalation whereas intercalation in sumf1^−/− larvae (E) was disrupted in some areas (outlined) and stacked elsewhere (red star). (C,F). At 10 d.p.f. (C&F, n = 3 per genotype), the intercalation of chondrocytes was disrupted in (F) sumf1^−/− larvae (asterisk and red box) when compared to (C) wildtype (asterisk). Scalebar represents 200 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sumf1^{la015919Tg/la015919Tg} (TL)
Observed In:	cranial cartilage chondrocyte
Stage Range:	Day 5 to Days 7-13

Phenotype Detail

Acknowledgments

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