ZFIN ID: ZDB-FIG-200917-14
Page et al., 2019 - Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Reports   27:3139-3151.e5 Full text @ Cell Rep.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Conditions:
Knockdown Reagent:
Anatomical Terms:
Stage Range: 26+ somites to Prim-15
PHENOTYPE:
Fish:
Conditions:
Knockdown Reagent:
Observed In:
Stage Range: 26+ somites to Prim-15

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
avpr1ab s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
ccl38.1 s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
dll4 WT chemical treatment: semaxanib Prim-15 whole organism RTPCR
EGFP s843Tg standard conditions 26+ somites dorsal aorta IFL
Prim-5 intersegmental vessel IFL
Prim-15 intersegmental vessel IFL
flt4 WT chemical treatment: semaxanib Prim-15 whole organism RTPCR
hlx1 s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
hmgcra s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
kdrl WT chemical treatment: semaxanib Prim-15 whole organism RTPCR
WT + MO1-dll4 standard conditions Prim-15 whole organism RTPCR
lft2 s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
mfng s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
mia s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
tm4sf18 WT standard conditions 26+ somites dorsal aorta ISH
Prim-5 intersegmental vessel ISH
Prim-15 intersegmental vessel ISH
WT chemical treatment: semaxanib Prim-15 whole organism RTPCR
WT + MO1-dll4 standard conditions 26+ somites dorsal aorta ISH
Prim-15 whole organism RTPCR
npas4ls5/s5 standard conditions 26+ somites Not Detected dorsal aorta ISH
s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
tmem204 s843Tg control Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT Prim-15 endothelial cell OTHR
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell OTHR
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell OTHR
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT chemical treatment: semaxanib Prim-15 whole organism dll4 expression decreased amount, abnormal
Prim-15 whole organism flt4 expression decreased amount, abnormal
Prim-15 whole organism kdrl expression decreased amount, abnormal
Prim-15 whole organism tm4sf18 expression decreased amount, abnormal
WT + MO1-dll4 standard conditions 26+ somites dorsal aorta tm4sf18 expression increased distribution, abnormal
Prim-15 whole organism kdrl expression increased amount, abnormal
Prim-15 whole organism tm4sf18 expression increased amount, abnormal
npas4ls5/s5 standard conditions 26+ somites dorsal aorta tm4sf18 expression absent, abnormal
s843Tg control Prim-15 endothelial cell avpr1ab expression decreased amount, abnormal
Prim-15 endothelial cell ccl38.1 expression amount, ameliorated
Prim-15 endothelial cell hlx1 expression amount, ameliorated
Prim-15 endothelial cell hmgcra expression amount, ameliorated
Prim-15 endothelial cell lft2 expression amount, ameliorated
Prim-15 endothelial cell mfng expression amount, ameliorated
Prim-15 endothelial cell mia expression amount, ameliorated
Prim-15 endothelial cell tm4sf18 expression amount, ameliorated
Prim-15 endothelial cell tmem204 expression amount, ameliorated
s843Tg chemical treatment: DAPT Prim-15 endothelial cell avpr1ab expression increased amount, abnormal
Prim-15 endothelial cell ccl38.1 expression increased amount, abnormal
Prim-15 endothelial cell hlx1 expression increased amount, abnormal
Prim-15 endothelial cell hmgcra expression increased amount, abnormal
Prim-15 endothelial cell lft2 expression increased amount, abnormal
Prim-15 endothelial cell mfng expression increased amount, abnormal
Prim-15 endothelial cell mia expression increased amount, abnormal
Prim-15 endothelial cell tm4sf18 expression increased amount, abnormal
Prim-15 endothelial cell tmem204 expression increased amount, abnormal
s843Tg chemical treatment: DAPT, chemical treatment: semaxanib Prim-15 endothelial cell avpr1ab expression decreased amount, abnormal
Prim-15 endothelial cell ccl38.1 expression decreased amount, abnormal
Prim-15 endothelial cell hlx1 expression decreased amount, abnormal
Prim-15 endothelial cell hmgcra expression decreased amount, abnormal
Prim-15 endothelial cell lft2 expression decreased amount, abnormal
Prim-15 endothelial cell mfng expression decreased amount, abnormal
Prim-15 endothelial cell mia expression decreased amount, abnormal
Prim-15 endothelial cell tm4sf18 expression decreased amount, abnormal
Prim-15 endothelial cell tmem204 expression amount, ameliorated
s843Tg chemical treatment: semaxanib Prim-15 endothelial cell avpr1ab expression decreased amount, abnormal
Prim-15 endothelial cell ccl38.1 expression decreased amount, abnormal
Prim-15 endothelial cell hlx1 expression decreased amount, abnormal
Prim-15 endothelial cell hmgcra expression decreased amount, abnormal
Prim-15 endothelial cell lft2 expression decreased amount, abnormal
Prim-15 endothelial cell mfng expression decreased amount, abnormal
Prim-15 endothelial cell mia expression decreased amount, abnormal
Prim-15 endothelial cell tm4sf18 expression decreased amount, abnormal
Prim-15 endothelial cell tmem204 expression decreased amount, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Rep.