ZFIN ID: ZDB-GENE-990630-11
Gene Name: lefty2
Gene Symbol: lft2    Nomenclature History

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Previous Names: atv2 (1), cb720 (1), fe38b03, wu:fe38b03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have cytokine activity and transforming growth factor beta receptor binding activity. Involved in heart field specification and mesoderm development. Predicted to localize to the extracellular space. Is expressed in several structures, including blastodisc; cardiovascular system; central nervous system; hypoblast; and mesoderm. Orthologous to human LEFTY2 (left-right determination factor 2).
Genome Resources: Alliance (1),  Gene:30146 (1),  Ensembl(GRCz11):ENSDARG00000044059 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a146 Small Deletion Unknown Frameshift, Premature Stop TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-lft2 N/A 4
MO2-lft2 N/A 3
MO3-lft2 N/A 1
MO4-lft2 N/A 1
TALEN1-lft2
1
TALEN2-lft2 1
DISEASE ASSOCIATED WITH lft2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH lft2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart field specification (more)
Cellular Component extracellular region (more)
Molecular Function cytokine activity (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR003942 Left- Right determination factor
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA lft2-201 (1)    Ensembl 1318
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
AB1-lft2 polyclonal 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lft2 No data available
MARKER RELATIONSHIPS
lft2 Contained in: [BAC] CH211-236P5 (1)
lft2 Encodes: [EST] cb720 (1) (order this), fe38b03
[cDNA] MGC:114024 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_130961 (1) 1315 nt
Genomic GenBank:BX248131 (1) 162685 nt
Select Tool
Polypeptide UniProtKB:A0A0B5JW28 (1) 362 aa
Sequence Information (all 16)
ORTHOLOGY for lft2 ( Chr: 17 )
CITATIONS (150)