Gene
flt4
- ID
- ZDB-GENE-980526-326
- Name
- fms related receptor tyrosine kinase 4
- Symbol
- flt4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Exhibits identical protein binding activity. Involved in several processes, including motor neuron axon guidance; regulation of signal transduction; and vasculature development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including angioblastic mesenchymal cell; endothelial cell; intermediate cell mass of mesoderm; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 161 figures from 125 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1059 (11 images)
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008266 | Tyrosine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Domain | IPR003598 | Immunoglobulin subtype 2 |
Domain | IPR003599 | Immunoglobulin subtype |
Domain | IPR007110 | Immunoglobulin-like domain |
Domain | IPR013098 | Immunoglobulin I-set |
Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
Domain | IPR041348 | VEGFR-2, transmembrane domain |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
Protein | Length | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site | VEGFR-2, transmembrane domain |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q5MD89
|
1357 | ||||||||||||||
UniProtKB:A0A8M3AZL8
|
1364 | ||||||||||||||
UniProtKB:A0A0R4IFS9
|
1368 | ||||||||||||||
UniProtKB:A0A2R8QSE0
|
1324 |
Interactions and Pathways
No data available
Plasmids