Gene

flt4

ID
ZDB-GENE-980526-326
Name
fms related receptor tyrosine kinase 4
Symbol
flt4 Nomenclature History
Previous Names
  • cb1059 (1)
  • expando (1)
  • VEGFR3
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Exhibits identical protein binding activity. Involved in several processes, including motor neuron axon guidance; regulation of signal transduction; and vasculature development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including angioblastic mesenchymal cell; endothelial cell; intermediate cell mass of mesoderm; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
Genome Resources
Note
None
Expression
All Expression Data
148 figures from 114 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With flt4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary lymphedema IA Alliance Lymphatic malformation 1 153100
Congenital heart defects, multiple types, 7 618780
Hemangioma, capillary infantile, somatic 602089
Associated With flt4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013151 Immunoglobulin
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041348 VEGFR-2, Transmembrane domain
Family IPR009137 Vascular endothelial growth factor receptor 3 (VEGFR3)
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site Vascular endothelial growth factor receptor 3 (VEGFR3) VEGFR-2, Transmembrane domain
UniProtKB:A0A0R4IFS9 1368
UniProtKB:Q5MD89 1357
UniProtKB:A0A2R8QSE0 1324
UniProtKB:Q9PUL0 404
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-flt4 polyclonal Rabbit
  • IHC
Kerafast
3
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations