Gene
flt4
- ID
- ZDB-GENE-980526-326
- Name
- fms related receptor tyrosine kinase 4
- Symbol
- flt4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Exhibits identical protein binding activity. Involved in several processes, including motor neuron axon guidance; regulation of signal transduction; and vasculature development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including angioblastic mesenchymal cell; endothelial cell; intermediate cell mass of mesoderm; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).
- Genome Resources
- Note
- None
- All Expression Data
- 148 figures from 114 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 28 figures from 14 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary lymphedema IA | Alliance | Lymphatic malformation 1 | 153100 |
| Congenital heart defects, multiple types, 7 | 618780 | ||
| Hemangioma, capillary infantile, somatic | 602089 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001824 | Tyrosine-protein kinase, receptor class III, conserved site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR003598 | Immunoglobulin subtype 2 |
| Domain | IPR003599 | Immunoglobulin subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013098 | Immunoglobulin I-set |
| Domain | IPR013151 | Immunoglobulin |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR041348 | VEGFR-2, Transmembrane domain |
| Family | IPR009137 | Vascular endothelial growth factor receptor 3 (VEGFR3) |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin | Immunoglobulin I-set | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Immunoglobulin subtype | Immunoglobulin subtype 2 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase, receptor class III, conserved site | Vascular endothelial growth factor receptor 3 (VEGFR3) | VEGFR-2, Transmembrane domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IFS9
|
1368 | ||||||||||||||||
|
UniProtKB:Q5MD89
|
1357 | ||||||||||||||||
|
UniProtKB:A0A2R8QSE0
|
1324 | ||||||||||||||||
|
UniProtKB:Q9PUL0
|
404 |
Interactions and Pathways
No data available
Plasmids