ZFIN ID: ZDB-GENE-980526-326
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.
Gene Name: fms-related tyrosine kinase 4
Gene Symbol: flt4
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cb1059 (1), expando (1), VEGFR3

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 14 Mapping Details/Browsers
AUTOMATED DESCRIPTION
Exhibits protein homodimerization activity; involved in several processes, including motor neuron axon guidance, regulation of signal transduction, and vasculature development; predicted to localize  ...
GENE EXPRESSION
All Expression Data: 129 figures from 101 publications
Directly Submitted Expression Data: 4 figures (11 images) from Thisse et al., 2001 [cb1059]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu4602 Point Mutation Unknown Unknown
la027502Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa281 Point Mutation Unknown Premature Stop ENU
    sa9798 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa16036 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa30675 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa31980 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35675 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35676 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35677 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42378 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa44806 Point Mutation Unknown Unknown ENU
    um131 Indel Unknown Frameshift, Premature Stop TALEN
    um159 Small Deletion Exon 12 Unknown TALEN
    um200 Small Deletion Unknown Inframe Deletion TALEN
    um203 Small Deletion Unknown Frameshift, Premature Stop TALEN
    Targeting reagents:
    PHENOTYPE
    Data: 26 figures from 13 publications
    Observed in:
    DISEASE ASSOCIATED WITH flt4 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hereditary lymphedema IA Lymphatic malformation 1 153100
    Hemangioma, capillary infantile, somatic 602089
    DISEASE ASSOCIATED WITH flt4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein homodimerization activity (more)
    GO Terms (all 36)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001824 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR009137 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR036179 (1)
  • InterPro:IPR041348 (1)
    		•
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00240 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
    		•
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF17988 (1)
    		•
  • EC:2.7.10.1 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA flt4-201 (1) 4439
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM flt4
    MARKER RELATIONSHIPS
    flt4Contained in: [BAC] CH211-198F4 (1) (order this), DKEY-58G10 (1) (order this)
    flt4Encodes: [EST] cb1059 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130945 (1) 4473bp
    Select Tool
    Genomic GenBank:CR381700 (1) 203630bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IFS9 (1) 1368aa
    Select Tool
    Sequence Clusters UniGene:81298 (1)
    Sequence Information (all 22)
    OTHER flt4 GENE PAGES
  • Alliance (1)
  • Gene:30121 (1)
  • VEGA:OTTDARG00000020901 (1)
  • Ensembl(GRCz11):ENSDARG00000104453 (1)
    • ORTHOLOGY for flt4 (Chr: 14)
    CITATIONS (213)