Gene

flt4

ID

ZDB-GENE-980526-326

Name

fms related receptor tyrosine kinase 4

Symbol

flt4 Nomenclature History

Previous Names

cb1059 (1)
expando (1)
VEGFR3

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Exhibits identical protein binding activity. Involved in several processes, including motor neuron axon guidance; regulation of signal transduction; and vasculature development. Predicted to localize to integral component of plasma membrane and receptor complex. Is expressed in several structures, including angioblastic mesenchymal cell; endothelial cell; intermediate cell mass of mesoderm; mesoderm; and vasculature. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4).

Genome Resources

Note

None

Expression

All Expression Data

150 figures from 116 publications

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

cb1059 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 28 figures from 14 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With flt4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
hereditary lymphedema IA	Alliance	Lymphatic malformation 1	153100
		Congenital heart defects, multiple types, 7	618780
		Hemangioma, capillary infantile, somatic	602089

Associated With flt4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Conserved_site	IPR001824	Tyrosine-protein kinase, receptor class III, conserved site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013151	Immunoglobulin
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR041348	VEGFR-2, Transmembrane domain
Family	IPR009137	Vascular endothelial growth factor receptor 3 (VEGFR3)
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily