ZFIN ID: ZDB-GENE-980526-326
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Gene Name: fms related receptor tyrosine kinase 4
Gene Symbol: flt4    Nomenclature History

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Previous Names: cb1059 (1), expando (1), VEGFR3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits protein homodimerization activity. Involved in several processes, including motor neuron axon guidance; regulation of signal transduction; and vasculature development. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Is expressed in several structures, including angioblastic mesenchymal cell; endothelial cell; intermediate cell mass of mesoderm; mesoderm; and vasculature. Orthologous to human FLT4 (fms related tyrosine kinase 4).
Genome Resources: Alliance (1),  Gene:30121 (1),  Ensembl(GRCz11):ENSDARG00000104453 (1)
GENE EXPRESSION
All Expression Data: 134 figures from 105 publications
Directly Submitted Expression Data: 4 figures (11 images) from Thisse et al., 2001 [cb1059]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu4602 Point Mutation Unknown Missense
la027502Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa281 Point Mutation Unknown Premature Stop ENU
    sa9798 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa16036 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa30675 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa31980 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35675 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35676 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa35677 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42378 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa44806 Point Mutation Unknown Unknown ENU
    um131 Indel Unknown Frameshift, Premature Stop TALEN
    um159 Small Deletion Exon 12 Unknown TALEN
    um200 Small Deletion Unknown Inframe Deletion TALEN
    um203 Small Deletion Unknown Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-flt4
    		1
    MO1-flt4 N/A 11
    MO2-flt4 N/A 1
    MO3-flt4 N/A 18
    TALEN1-flt4
    		1
    TALEN2-flt4 2
    TALEN3-flt4
    		1
    TALEN4-flt4 1
    TALEN5-flt4 2
    TALEN6-flt4
    		1
    TALEN7-flt4
    		1
    PHENOTYPE
    Data: 26 figures from 13 publications
    Observed in:
    DISEASE ASSOCIATED WITH flt4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary lymphedema IA Alliance Lymphatic malformation 1 153100
    Hemangioma, capillary infantile, somatic 602089
    DISEASE ASSOCIATED WITH flt4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function identical protein binding (more)
    GO Terms (all 39)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Family IPR009137 Vascular endothelial growth factor receptor 3 (VEGFR3)
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Domain IPR041348 VEGFR-2, Transmembrane domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA flt4-201 (1)    Ensembl 4439
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-flt4 polyclonal Rabbit IHC Kerafast
    		3
    PLASMIDS
    Addgene:37 p flt4
    Addgene:pCS-Fv2Eflt4um200-2a-tdTomato
    Addgene:pCS-flt4um159-HA
    CONSTRUCTS WITH SEQUENCES FROM flt4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(fli1:flt4-2A-mCherry) fli1 2A,  flt4,  mCherry Danio rerio 1 1
    Tg(flt4:YFP) flt4 YFP Danio rerio 1 5
    Tg(hsp70l:flt4,cryaa:Cerulean) cryaa,  hsp70l Cerulean,  flt4 Danio rerio 1 2
    TgBAC(flt4:Citrine) flt4 Citrine Danio rerio 1 14
    MARKER RELATIONSHIPS
    flt4 Contained in: [BAC] CH211-198F4 (1), DKEY-58G10 (1) (order this)
    flt4 Encodes: [EST] cb1059 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130945 (1) 4473 bp
    Select Tool
    Genomic GenBank:CR381700 (1) 203630 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IFS9 (1) 1368 aa
    Select Tool
    Sequence Information (all 21)
    ORTHOLOGY for flt4 ( Chr: 14 )
    CITATIONS (230)