ZFIN ID: ZDB-GENE-000705-1
Gene Name: kinase insert domain receptor like
Gene Symbol: kdrl    Nomenclature History

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Previous Names: kdr, kdra (1), fetal liver kinase, flk-1, flk1 (1), flk, flt1b (1), VEGFR-2 (1), vegfr2, vegfr2a (1), vegfr4, vegr2, wu:fk52c05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits protein tyrosine kinase activity. Involved in circulatory system development and thyroid gland development. Predicted to localize to the integral component of plasma membrane and receptor complex. Is expressed in several structures, including cardiovascular system; head; hematopoietic system; mesoderm; and pleuroperitoneal region.
Genome Resources: Alliance (1),  Gene:796537 (1),  Ensembl(GRCz11):ENSDARG00000105215 (1)
GENE EXPRESSION
All Expression Data: 283 figures from 209 publications
Directly Submitted Expression Data: 6 figures (27 images) from Thisse et al., 2008 [cssl:d0146]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu5088 Point Mutation Unknown Unknown ENU
ihb123 Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • ion38Tg Transgenic Insertion Intron 29 Unknown DNA_AND_CRISPR
    la010852Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018984Tg Transgenic Insertion Unknown Unknown DNA
    la027548Tg Transgenic Insertion Unknown Unknown DNA
    sa9469 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15912 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19086 Point Mutation Unknown Splice Site ENU
    sa28333 Point Mutation Unknown Premature Stop ENU
    sa44810 Point Mutation Unknown Unknown ENU
    sa44811 Point Mutation Unknown Unknown ENU
    sa45520 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t20257 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • t21588 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • um6 Point Mutation Unknown Missense ENU
    um19 Small Deletion Exon 2 Frameshift ZINC_FINGER_NUCLEASE
    y17 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kdrl 1
    CRISPR2-kdrl 1
    MO1-kdrl N/A 13
    MO2-kdrl N/A 5
    MO3-kdrl N/A 2
    MO4-kdrl N/A 8
    MO5-kdrl N/A 1
    DISEASE ASSOCIATED WITH kdrl HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH kdrl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein tyrosine kinase activity (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Domain IPR013151 Immunoglobulin
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Domain IPR041348 VEGFR-2, Transmembrane domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdrl-201 (1)    Ensembl 5790
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-kdrl polyclonal Rabbit Kerafast
    2
    Ab1-kdrl polyclonal IgG Rabbit IHC Thermo Fisher Scientific (Lab Vision)
    2
    CONSTRUCTS WITH SEQUENCES FROM kdrl
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-6.5kdrl:mCherry) kdrl mCherry Danio rerio 1 42
    Tg(-6.5kdrl:NLS-mCherry) kdrl mCherryNLS Danio rerio 2 6
    Tg(-7kdrl:EGFP) kdrl EGFP Danio rerio 1 2
    Tg(kdrl:Cerulean) kdrl Cerulean Danio rerio 1 2
    Tg(kdrl:CFP) kdrl CFP Danio rerio 1 3
    tg(kdrl:cfp-ntr) kdrl CFPNTR Danio rerio 1 1
    Tg(kdrl:copGFP) kdrl copGFP Danio rerio 1 2
    Tg(kdrl:Cre) kdrl Cre Danio rerio 1 14
    Tg(kdrl:Cre-ERT2) kdrl CreERT2 Danio rerio 1 4
    Tg(kdrl:ctnna-EGFP) kdrl ctnna1EGFP Danio rerio 1 4
    Tg(kdrl:cxcr1,myl7:EGFP) kdrlmyl7 cxcr1EGFP Danio rerio 1 1
    Tg(kdrl:Dendra2) kdrl Dendra2 Danio rerio 1 3
    Tg(kdrl:Dendra2-NTR) kdrl Dendra2NTR Danio rerio 1 2
    Tg(kdrl:dnHsa.JUNB,GFP) kdrl GFP Danio rerioHomo sapiens 1 1
    Tg(kdrl:DsRed) kdrl DsRed Danio rerio 1 2
    Tg(kdrl:DsRed2) kdrl DsRed2 Danio rerio 1 22
    Tg(kdrl:Eco.BirA-Hsa.HRAS-mCherry) kdrl mCherry Danio rerioEscherichia coli 1 2
    Tg(kdrl:EGFP) kdrl EGFP Danio rerio 3 512
    Tg(kdrl:GAL4) kdrl GAL4 Danio rerio 1 6
    Tg(kdrl:GAL4,14xUAS-Eb1:EGFP) kdrlUAS EGFPGAL4 Danio rerio 1 5
    Tg(kdrl:GAL4-VP16) kdrl GAL4VP16 Danio rerio 1 2
    tg(kdrl:gal4ff) kdrl GAL4FF Danio rerio 1 2
    Tg(kdrl:GAL4FF-2A-mCherry) kdrl 2AGAL4FFmCherry Danio rerio 1 4
    Tg(kdrl:GCaMP5) kdrl GCaMP Danio rerio 1 1
    Tg(kdrl:GFP) kdrl GFP Danio rerio 2 144
    Tg(kdrl:grcfp) kdrl grcfp Danio rerio 3 71
    Tg(kdrl:hist2h2l-EGFP) kdrl EGFPhist2h2l Danio rerio 1 7
    Tg(kdrl:Hsa.GLRX-roGFP2) kdrl roGFP Danio rerioHomo sapiens 2 2
    Tg(kdrl:Hsa.HRAS-mCherry) kdrl mCherry Danio rerioHomo sapiens 2 201
    Tg(kdrl:Hsa.MAPRE3-GFP) kdrl GFP Danio rerioHomo sapiens 1 1
    Tg(kdrl:Hsa.PAK1-Hsa.KRAS) kdrl Danio rerioHomo sapiens 1 1
    Tg(kdrl:Kaede) kdrl Kaede Danio rerio 2 3
    Tg(kdrl:LIFEACT-DsRed) kdrl DsRedLIFEACT Danio rerio 1 1
    Tg(kdrl:LIFEACT-EGFP) kdrl EGFPLIFEACT Danio rerio 1 1
    Tg(kdrl:LOX2272-LOXP-Tomato-LOX2272-Cerulean-LOXP-EYFP) kdrl CeruleanEYFPTomato Danio rerio 1 2
    Tg(kdrl:mApple) kdrl mApple Danio rerio 1 1
    Tg(kdrl:mCherry) kdrl mCherry Danio rerio 1 34
    Tg(kdrl:mCherry-actb1) kdrl actb1mCherry Danio rerio 1 4
    Tg(kdrl:mCherry-CAAX) kdrl mCherry Danio rerio 1 16
    Tg(kdrl:mCherry-cdt1) kdrl cdt1mCherry Danio rerio 1 4
    Tg(kdrl:mCherry-NTR) kdrl mCherryNTR Danio rerio 1 1
    Tg(kdrl:MITO-Hsa.GLRX-roGFP2) kdrl MITOroGFP Danio rerioHomo sapiens 1 2
    Tg(kdrl:MITO-roGFP2-Sce.Hyr1) kdrl MITOroGFP Danio rerioSaccharomyces cerevisiae 1 2
    Tg(kdrl:MKATE2-NLS) kdrl MKATE2 Danio rerio 1 3
    Tg(kdrl:mRFP) kdrl mRFP Danio rerio 1 2
    Tg(kdrl:mRFPF) kdrl mRFP Danio rerio 1 2
    Tg(kdrl:msna-EGFP) kdrl EGFPmsna Danio rerio 1 9
    Tg(kdrl:mVenus-gmnn) kdrl gmnnVenus Danio rerio 1 4
    Tg(kdrl:myl9a-EGFP) kdrl EGFPmyl9a Danio rerio 1 1
    Tg(kdrl:myl9b-EGFP) kdrl EGFPmyl9b Danio rerio 1 1
    Tg(kdrl:NLS-EGFP) kdrl EGFPNLS Danio rerio 1 40
    Tg(kdrl:NLS-Eos) kdrl Eos Danio rerio 1 7
    Tg(kdrl:NLS-Hsa.GLRX-roGFP2) kdrl NLSroGFP Danio rerioHomo sapiens 1 2
    tg(kdrl:nls-kaede) kdrl KaedeNLS Danio rerio 1 1
    Tg(kdrl:NLS-KikGR) kdrl KikGRNLS Danio rerio 1 6
    Tg(kdrl:NLS-mCherry) kdrl mCherry Danio rerio 1 9
    Tg(kdrl:NLS-roGFP2-Sce.Hyr1) kdrl NLSroGFP Danio rerioSaccharomyces cerevisiae 1 2
    Tg(kdrl:pecam1-GFP) kdrl GFPpecam1 Danio rerio 1 1
    Tg(kdrl:pku300) kdrl pku300 Danio rerio 1 3
    Tg(kdrl:pku300-mCherry) kdrl mCherrypku300 Danio rerio 1 2
    Tg(kdrl:RaichuEV) kdrl RaichuEV Danio rerio 1 1
    Tg(kdrl:RFP) kdrl RFP Danio rerio 1 20
    Tg(kdrl:RFP-CAAX) kdrl CAAXRFP Danio rerio 1 3
    Tg(kdrl:roGFP2-Sce.Hyr1) kdrl roGFP Danio rerioSaccharomyces cerevisiae 1 2
    Tg(kdrl:TagBFP) kdrl TagBFP Danio rerio 1 2
    Tg(kdrl:TagRFP-CAAX) kdrl TagRFP Danio rerio 1 2
    Tg(kdrl:tdEos) kdrl EostdEos Danio rerio 1 2
    Tg(kdrl:Tomato) kdrl Tomato Danio rerio 1 1
    Tg(kdrl:ubiad1) kdrl ubiad1 Danio rerio 1 2
    Tg(kdrl:ubiad1,mCherry) kdrl mCherryubiad1 Danio rerio 1 2
    Tg(UAS:kdrl,NLS-mCherry) UAS kdrlmCherryNLS Danio rerio 1 1
    Tg1(kdrl:NLS-mCherry) kdrl mCherry Danio rerio 1 3
    Tg2(kdrl:copGFP) kdrl copGFP Danio rerio 1 1
    Tg2(kdrl:DsRed) kdrl DsRed Danio rerio 1 1
    Tg2(kdrl:GFP) kdrl GFP Danio rerio 1 1
    Tg2(kdrl:mCherry) kdrl mCherry Danio rerio 1 5
    Tg2(kdrl:mCherry-CAAX) kdrl CAAXmCherry Danio rerio 1 3
    Tg2(kdrl:NLS-mCherry) kdrl mCherry Danio rerio 1 3
    Tg3(kdrl:GFP) kdrl GFP Danio rerio 1 1
    Tg3(kdrl:mCherry) kdrl mCherry Danio rerio 1 3
    tg3(kdrl:mcherry-caax) kdrl CAAXmCherry Danio rerio 1 1
    Tg4(kdrl:mCherry) kdrl mCherry Danio rerio 1 10
    Tg5(kdrl:mCherry) kdrl mCherry Danio rerio 1 7
    Tg6(kdrl:mCherry) kdrl mCherry Danio rerio 1 2
    Tg7(kdrl:mCherry) kdrl mCherry Danio rerio 1 1
    Tg8(kdrl:mCherry) kdrl mCherry Danio rerio 1 1
    tg9(kdrl:mcherry) kdrl mCherry Danio rerio 1 2
    tg10(kdrl:mcherry) kdrl mCherry Danio rerio 1 2
    tg11(kdrl:mcherry) kdrl mCherry Danio rerio 1 1
    tg12(kdrl:mcherry) kdrl mCherry Danio rerio 1 1
    tg13(kdrl:mcherry) kdrl mCherry Danio rerio 1 1
    TgBAC(kdrl:LOXP-AmCyan-LOXP-ZsYellow) kdrl AmCyanZsYellow Danio rerio 1 6
    TgBAC(kdrl:mCherry-CAAX) kdrl CAAXmCherry Danio rerio 1 1
    TgBAC(kdrl:MKATE2-CAAX) kdrl MKATE2 Danio rerio 1 7
    MARKER RELATIONSHIPS
    kdrl Contained in: [BAC] CH211-231B5 (1), CH211-276G21 (1), DKEY-1A23 (1) (order this), DKEY-183E23 (1) (order this)
    kdrl Encodes: [EST] cssl:d0146 (1), fk52c05
    [cDNA] MGC:158203 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131472 (1) 3906 bp
    Genomic GenBank:CR759732 (1) 225630 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q8AXB3 (1) 1302 aa
    Sequence Information (all 38)
    ORTHOLOGY for kdrl ( Chr: 14 )
    CITATIONS (546)