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Gene

kdrl

ID
ZDB-GENE-000705-1
Name
kinase insert domain receptor like
Symbol
kdrl Nomenclature History
Previous Names
  • kdr
  • kdra (1)
  • fetal liver kinase
  • flk-1
  • flk1 (1)
  • flk
  • flt1b (1)
  • VEGFR-2 (1)
  • vegfr2
  • vegfr2a (1)
  • vegfr4
  • vegr2
  • wu:fk52c05
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Enables protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation. Acts upstream of or within circulatory system development and thyroid gland development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; head; hematopoietic system; mesoderm; and pleuroperitoneal region.
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
309 figures from 224 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 16 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kdrl Human Ortholog
No data available
Associated With kdrl Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013151 Immunoglobulin
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041348 VEGFR-2, Transmembrane domain
Family IPR009136 Vascular endothelial growth factor receptor 2 (VEGFR2)
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class III, conserved site Vascular endothelial growth factor receptor 2 (VEGFR2) VEGFR-2, Transmembrane domain
UniProtKB:A0A0R4IIR3 1301
UniProtKB:Q8AXB3 1302
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-kdrl polyclonal Rabbit
Kerafast
2
Ab1-kdrl polyclonal IgG Rabbit
  • IHC
Thermo Fisher Scientific (Lab Vision)
2
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations