Gene

hmgcra

ID
ZDB-GENE-040401-2
Name
3-hydroxy-3-methylglutaryl-CoA reductase a
Symbol
hmgcra Nomenclature History
Previous Names
  • hmgcr1 (1)
  • hmgcr1a
  • hmgra (1)
  • si:ch211-129a6.5
  • zgc:136576
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have hydroxymethylglutaryl-CoA reductase (NADPH) activity and hydroxymethylglutaryl-CoA reductase activity. Involved in skeletal muscle tissue development. Predicted to localize to endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in gut and liver. Human ortholog(s) of this gene implicated in several diseases, including asthma; coronary artery disease (multiple); dementia; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
21 figures from 16 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Hanai et al., 2007
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hmgcra Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
[Low density lipoprotein cholesterol level QTL 3]
[Statins, attenuated cholesterol lowering by]
Associated With hmgcra Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR023076 Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site
Domain IPR000731 Sterol-sensing domain
Family IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
Family IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
Family IPR004816 Hydroxymethylglutaryl-CoA reductase, metazoan
Homologous_superfamily IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
Homologous_superfamily IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
Homologous_superfamily IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
Homologous_superfamily IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
Domain Details Per Protein
Protein Length Hydroxymethylglutaryl-CoA reductase, class I/II Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily Hydroxymethylglutaryl-CoA reductase, class I/II, conserved site Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type Hydroxymethylglutaryl-CoA reductase, metazoan Hydroxymethylglutaryl-CoA reductase, N-terminal Sterol-sensing domain
UniProtKB:A0A2R8QHL5 912
UniProtKB:A0A2R8QRF7 884
UniProtKB:Q1ECY4 884
UniProtKB:A9JSZ0 884
UniProtKB:A2BGX2 893
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations