ZFIN ID: ZDB-FIG-190620-11
Clément et al., 2018 - Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals. Mechanisms of Development   155:1-7 Full text @ Mech. Dev.
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 1

The pillars do not form properly in cog4−/− mutants. Live images of the inner ear of cog4+/+ sibling (A, n = 34 larvae) and cog4−/− mutant larvae (B, n = 15 larvae). Red stars indicate the semicircular canals. Phalloidin staining of the inner ear of cog4+/+ sibling (C, n = 24 larvae) and cog4−/− mutant larvae (D, n = 25 larvae). Yellow arrowheads indicate the fusion plates that form in 100% (24 out of 24) of wild-type siblings (C). Red arrowhead points to the malformed pillar. One or more malformed pillars are observed in 84% (21 out of 25) of homozygous mutant larvae (D). Anterior to the left and dorsal to the top. 5 dpf.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
cog4b1312/b1312 standard conditions Day 5 inner ear decreased size, abnormal
Day 5 pillar of the semicircular canal malformed, abnormal
Day 5 semicircular canal aplastic/hypoplastic, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Mechanisms of Development for permission to reproduce figures from this article. Please note that this material may be protected by copyright.

Reprinted from Mechanisms of Development, 155, Clément, A., Blanco-Sánchez, B., Peirce, J.L., Westerfield, M., Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals, 1-7, Copyright (2018) with permission from Elsevier. Full text @ Mech. Dev.