|ZFIN ID: ZDB-FIG-191010-2|
The three cristae form in cog4−/− mutants. Phalloidin staining of cog4 sibling (A, n = 23 larvae) and cog4−/−mutant larvae (B, n = 22 larvae). Red arrow heads point to the cristae and inner ear is outlined in red (A, B). Because of the inner ear shape in cog4−/− mutant larvae, the three cristae could not be imaged on the same exact plan. Anterior to the left and dorsal to the top. 5 dpf.
|cog4b1312/b1312||standard conditions||Day 5||anterior crista present, normal|
|Day 5||inner ear morphology, abnormal|
|Day 5||lateral crista present, normal|
|Day 5||posterior crista present, normal|
ZFIN wishes to thank the journal Mechanisms of Development for permission to reproduce figures from this article.
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Reprinted from Mechanisms of Development, 155, Clément, A., Blanco-Sánchez, B., Peirce, J.L., Westerfield, M., Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals, 1-7, Copyright (2018) with permission from Elsevier. Full text @ Mech. Dev.