|ZFIN ID: ZDB-FIG-191010-3|
The secretion of proteoglycans from the epithelial projections is reduced in cog4−/− mutants. Paraffin sections of the inner ear anterior (C) and posterior projections (A, B, D, E, F–K) after Alcian blue staining in cog4+/+ (A, B, F–H; n = 6 larvae) and cog4−/− larvae (C–E, I–K; n = 7 larvae). Anterior to the left and dorsal to the top. 52 hpf.
|cog4b1312/b1312||standard conditions||Long-pec||extracellular matrix organization disrupted, abnormal|
|Long-pec||otic vesicle protrusion proteoglycan decreased amount, abnormal|
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Reprinted from Mechanisms of Development, 155, Clément, A., Blanco-Sánchez, B., Peirce, J.L., Westerfield, M., Cog4 is required for protrusion and extension of the epithelium in the developing semicircular canals, 1-7, Copyright (2018) with permission from Elsevier. Full text @ Mech. Dev.