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ZIRC
ZFIN ID: ZDB-FIG-131213-13
Geng et al., 2013 - Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene. Development (Cambridge, England)   40(21):4362-4374 Full text @ Development
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Genes:
Fish:
Anatomical Terms:
Stage Range: Long-pec to Day 5

Fig. 3 Expression of genes involved in endolymph homeostasis in the lau mutant ear. (A-D) The endolymphatic duct, marked by expression of bmp4 (arrowheads, A,B) and foxi1 (C,D), appears to develop normally in lau mutants. The three cristae also express bmp4 normally (asterisks, A,B). (E-J) Expression of ion transporter genes in the lau mutant ear. (E,F) Expression of the atp1a1a.4 subunit of Na+/K+-ATPase1 is more diffuse and lacking from the ventral pillar (vp). (G-J) There is a substantial reduction in both kcnq1 and nkcc1 expression. Abbreviation: vp, ventral pillar (E) or ventral projection (F). Alleles: B,D,H,J, tk256a; F, tb233c. Scale bars: 50 μm.

Gene Expression Details
Gene Antibody Fish Conditions Stage Qualifier Anatomy Assay
atp1a1a.4 WT standard conditions Protruding-mouth pillar of the lateral semicircular canal ISH
Protruding-mouth semicircular canal ISH
adgrg6tb233c/tb233c standard conditions Protruding-mouth Not Detected pillar of the lateral semicircular canal ISH
Protruding-mouth semicircular canal ISH
bmp4 WT standard conditions Long-pec anterior semicircular canal ISH
Long-pec endolymphatic duct ISH
Long-pec lateral semicircular canal ISH
Long-pec posterior semicircular canal ISH
adgrg6tk256a/tk256a standard conditions Long-pec anterior semicircular canal ISH
Long-pec endolymphatic duct ISH
Long-pec lateral semicircular canal ISH
Long-pec posterior semicircular canal ISH
foxi1 WT standard conditions Protruding-mouth endolymphatic duct ISH
adgrg6tk256a/tk256a standard conditions Protruding-mouth endolymphatic duct ISH
kcnq1.1 WT standard conditions Protruding-mouth semicircular canal ISH
adgrg6tk256a/tk256a standard conditions Protruding-mouth semicircular canal ISH
slc12a2 WT standard conditions Day 5 semicircular canal ISH
adgrg6tk256a/tk256a standard conditions Day 5 semicircular canal ISH
Antibody Labeling Details No data available
Phenotype Details No data available
Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Development