Gene

kcnq1.1

ID
ZDB-GENE-061214-5
Name
potassium voltage-gated channel, KQT-like subfamily, member 1.1
Symbol
kcnq1.1 Nomenclature History
Previous Names
  • kcnq1
  • zgc:158384
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have calmodulin binding activity and voltage-gated potassium channel activity. Involved in cardiac muscle cell action potential; kidney development; and renal filtration. Predicted to localize to voltage-gated potassium channel complex. Is expressed in brain; heart; and inner ear. Human ortholog(s) of this gene implicated in heart conduction disease (multiple) and long QT syndrome (multiple). Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1).
Genome Resources
Note
None
Expression
All Expression Data
6 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Liu et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnq1.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial atrial fibrillation Alliance Atrial fibrillation, familial, 3 607554
Jervell-Lange Nielsen syndrome Alliance Jervell and Lange-Nielsen syndrome 220400
long QT syndrome 1 Alliance Long QT syndrome 1 192500
long QT syndrome 1 Alliance {Long QT syndrome 1, acquired, susceptibility to} 192500
short QT syndrome Alliance Short QT syndrome 2 609621
Associated With kcnq1.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005821 Ion transport domain
Domain IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminal
Family IPR003937 Potassium channel, voltage dependent, KCNQ
Family IPR005827 Potassium channel, voltage dependent, KCNQ1
Family IPR028325 Voltage-gated potassium channel
Domain Details Per Protein
Protein Length Ion transport domain Potassium channel, voltage dependent, KCNQ Potassium channel, voltage dependent, KCNQ1 Potassium channel, voltage dependent, KCNQ, C-terminal Voltage-gated potassium channel
UniProtKB:A0A286YA22 643
UniProtKB:B0R0K2 655
UniProtKB:A1L1U6 485
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations