ZFIN ID: ZDB-GENE-001212-4
Gene Name: ATPase Na+/K+ transporting subunit alpha 1a, tandem duplicate 4
Gene Symbol: atp1a1a.4    Nomenclature History

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Previous Names: atp[a]1A1 (1), cb708 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have sodium:potassium-exchanging ATPase activity. Predicted to be involved in cellular monovalent inorganic cation homeostasis and inorganic cation transmembrane transport. Predicted to localize to integral component of membrane. Is expressed in several structures, including cardiovascular system; immature eye; integument; nervous system; and pronephros. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1).
Genome Resources: Alliance (1),  Gene:64615 (1),  Ensembl(GRCz11):ENSDARG00000001870 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13870 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14079 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14454 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17542 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19396 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19397 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32576 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32577 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39529 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44502 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zko57a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-atp1a1a.4 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH atp1a1a.4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 2DD Alliance Charcot-Marie-Tooth disease, axonal, type 2DD 618036
    Hypomagnesemia, seizures, and mental retardation 2 618314
    DISEASE ASSOCIATED WITH atp1a1a.4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp1a1a.4-201 (1)    Ensembl 3246
    ncRNA atp1a1a.4-002 (1)    Ensembl 887
    atp1a1a.4-003 (1)    Ensembl 664
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp1a1a.4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(atp1a1a.4:EGFP) atp1a1a.4 EGFP Danio rerio 1 15
    MARKER RELATIONSHIPS
    atp1a1a.4 Contained in: [BAC] DKEY-208K14 (1) (order this)
    atp1a1a.4 Encodes: [EST] cb708 (2) (order this), eu300 (1)
    [cDNA] MGC:64170 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131689 (1) 3270 nt
    Genomic GenBank:CU185242 (1) 180192 nt
    Select Tool
    Polypeptide UniProtKB:B8JKS7 (1) 1024 aa
    Sequence Information (all 21)
    ORTHOLOGY for atp1a1a.4 ( Chr: 1 )
    CITATIONS (44)