FIGURE

Fig. 2

ID

ZDB-FIG-081125-4

Publication

Morton et al., 2008 - microRNA-138 modulates cardiac patterning during embryonic development

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Fig. 2

miR-138 knockdown leads to expansion of AVC-specific gene expression into the ventricle. (A–H) Ventral views of 48-hpf embryos after mRNA in situ hybridization focusing on head (h) and heart (dotted lines) regions. Atrial (A and B) and ventricular (C and D) markers were similar in wild-type (wt) (A and C) and miR-138^mo-1 embryos (B and D). Expression of AVC-specific markers cspg2 (E and F) and notch1b (G and H) expanded into the ventricles (v) in miR-138^mo-1 embryos (F and H) but not in wild-type embryos (E and G). (a, atrium; amhc, atrial myosin heavy chain; vmhc, ventricular myosin heavy chain.)

Expression Data

Genes:	myh6 myh7 notch1b vcana
Fish:	AB AB + MO1-dre-mir-138
Knockdown Reagent:	MO1-dre-mir-138
Anatomical Terms:	atrioventricular canal atrium cardiac ventricle
Stage:	Long-pec

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-dre-mir-138
Knockdown Reagent:	MO1-dre-mir-138
Observed In:	cardiac ventricle development
Stage:	Long-pec

Phenotype Detail

Acknowledgments

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Open Access.

Full text @ Proc. Natl. Acad. Sci. USA