ZFIN ID: ZDB-GENE-031112-1
Gene Name: myosin, heavy chain 6, cardiac muscle, alpha
Gene Symbol: myh6    Nomenclature History

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Previous Names: amhc (1), atrial myosin heavy chain (1), unm s459, unm_s459, wea, weak atrium

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in heart contraction and heart development. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in atrial heart septal defect (multiple); heart conduction disease (multiple); and intrinsic cardiomyopathy (multiple). Is expressed in cardiac muscle; heart primordium; heart rudiment; and pericardial region. Orthologous to human MYH6 (myosin heavy chain 6).
Genome Resources: Alliance (1),  Gene:386711 (1),  Ensembl(GRCz11):ENSDARG00000090637 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dhu423 Point Mutation Unknown Unknown
m58 Small Deletion Unknown Frameshift ENU
m118 Unknown Unknown Unknown ENU
m229 Unknown Unknown Unknown ENU
m448 Unknown Unknown Unknown ENU
s459 Point Mutation Unknown Premature Stop ENU
s812 Point Mutation Unknown Premature Stop ENU
sa6659 Point Mutation Unknown Premature Stop ENU
sa12893 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25148 Point Mutation Unknown Premature Stop ENU
    sa37186 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37187 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37188 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sk7 Point Mutation Unknown Premature Stop ENU
    tw220a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-myh6 N/A 9
    MO2-myh6 N/A 1
    DISEASE ASSOCIATED WITH myh6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    atrial heart septal defect 3 Alliance Atrial septal defect 3 614089
    dilated cardiomyopathy 1EE Alliance Cardiomyopathy, dilated, 1EE 613252
    hypertrophic cardiomyopathy 14 Alliance Cardiomyopathy, hypertrophic, 14 613251
    {Sick sinus syndrome 3} 614090
    DISEASE ASSOCIATED WITH myh6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process atrial cardiac myofibril assembly (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001609 Myosin head, motor domain
    Domain IPR002928 Myosin tail
    Domain IPR004009 Myosin, N-terminal, SH3-like
    Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
    Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myh6-201 (1)    Ensembl 5935
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab-S46 monoclonal IgG1 , k Mouse IHC, WB Developmental Studies Hybridoma Bank
    103
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myh6
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-4.5myh6:EGFP) myh6 EGFP Danio rerio 1 2
    Tg(myh6:Cre-ERT2) myh6 CreERT2 Danio rerio 1 5
    Tg(myh6:Dendra) myh6 Dendra Danio rerio 1 1
    Tg(myh6:EGFP) myh6 EGFP Danio rerio 1 6
    Tg(myh6:myl4,cryaa:mCherry) cryaamyh6 mCherrymyl4 Danio rerio 1 1
    Tg(myh6:myl4_E17K,cryaa:mCherry) cryaamyh6 mCherrymyl4 Danio rerio 1 1
    Tg(myh6:NLS-tdEos) myh6 NLStdEos Danio rerio 1 1
    MARKER RELATIONSHIPS
    myh6 Contained in: [Fosmid] CH1073-184E3 (1)
    myh6 Encodes: [EST] eu557 (1), fc52a03 (1)
    [cDNA] MGC:195120 (1), MGC:195125 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198823 (1) 5946 bp
    Genomic GenBank:CU530419 (1) 38048 bp
    Select Tool
    Polypeptide UniProtKB:B3DJP9 (1) 1936 aa
    Sequence Information (all 23)
    ORTHOLOGY for myh6 ( Chr: 20 )
    CITATIONS (225)