ZFIN ID: ZDB-GENE-031112-1
Gene Name: myosin, heavy chain 6, cardiac muscle, alpha
Gene Symbol: myh6
Sequence Ontology ID : SO:0000704

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Previous Names: amhc (1), atrial myosin heavy chain (1), unm s459, unm_s459, wea, weak atrium

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have ATP binding activity, actin filament binding activity, and motor activity; involved in several processes, including animal organ development, animal organ development, and heart  ...
GENE EXPRESSION
All Expression Data: 136 figures from 109 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2005 [eu557]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dhu423 Point Mutation Unknown Unknown
m58 Small Deletion Unknown Frameshift ENU
m118 Unknown Unknown Unknown ENU
m229 Unknown Unknown Unknown ENU
m448 Unknown Unknown Unknown ENU
s459 Point Mutation Unknown Premature Stop ENU
s812 Point Mutation Unknown Premature Stop ENU
sa6659 Point Mutation Unknown Premature Stop ENU
sa12893 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25148 Point Mutation Unknown Premature Stop ENU
    sa37186 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37187 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37188 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sk7 Point Mutation Unknown Premature Stop ENU
    tw220a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 24 figures from 9 publications
    Observed in:
    DISEASE ASSOCIATED WITH myh6 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    atrial heart septal defect 3 Atrial septal defect 3 614089
    dilated cardiomyopathy 1EE Cardiomyopathy, dilated, 1EE 613252
    hypertrophic cardiomyopathy 14 Cardiomyopathy, hypertrophic, 14 613251
    {Sick sinus syndrome 3} 614090
    DISEASE ASSOCIATED WITH myh6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process atrial cardiac myofibril assembly (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000048 (1)
  • InterPro:IPR001609 (1)
  • InterPro:IPR002928 (1)
  • InterPro:IPR004009 (1)
  • InterPro:IPR008989 (1)
  • InterPro:IPR027401 (1)
  • InterPro:IPR027417 (1)
  • InterPro:IPR036961 (1)
  • PROSITE:PS50096 (1)
  • PROSITE:PS51456 (1)
  • PROSITE:PS51844 (1)
  • Pfam:PF00063 (1)
  • Pfam:PF01576 (1)
  • Pfam:PF02736 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA myh6-201 (1) 5935
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM myh6
    MARKER RELATIONSHIPS
    myh6Contained in: [Fosmid] CH1073-184E3 (1) (order this)
    myh6Encodes: [EST] eu557 (1), fc52a03 (1)
    [cDNA] MGC:195120 (1) (order this), MGC:195125 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_198823 (1) 5946bp
    Genomic GenBank:CU530419 (1) 38048bp
    Select Tool
    Polypeptide UniProtKB:B3DJP9 (1) 1936aa
    Sequence Clusters UniGene:29034 (1)
    Sequence Information (all 24)
    OTHER myh6 GENE PAGES
  • Alliance (1)
  • Gene:386711 (1)
  • VEGA:OTTDARG00000028853 (1)
  • Ensembl(GRCz11):ENSDARG00000090637 (1)
  • ORTHOLOGY for myh6 (Chr: 20)
    CITATIONS (213)