Gene
myh7
- ID
- ZDB-GENE-991123-5
- Name
- myosin heavy chain 7
- Symbol
- myh7 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in embryonic heart tube development and ventricular cardiac myofibril assembly. Predicted to localize to myosin complex. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); congenital heart disease (multiple); distal myopathy 1; heart conduction disease (multiple); and hyaline body myopathy (multiple). Is expressed in several structures, including heart primordium; heart rudiment; mesoderm; musculature system; and pericardial region. Orthologous to human MYH6 (myosin heavy chain 6) and MYH7 (myosin heavy chain 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 213 figures from 170 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Auman et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant hyaline body myopathy | Alliance | Congenital myopathy 7A, myosin storage, autosomal dominant | 608358 |
| autosomal recessive hyaline body myopathy | Alliance | Congenital myopathy 7B, myosin storage, autosomal recessive | 255160 |
| dilated cardiomyopathy 1S | Alliance | Cardiomyopathy, dilated, 1S | 613426 |
| dilated cardiomyopathy 1S | Alliance | Left ventricular noncompaction 5 | 613426 |
| distal myopathy 1 | Alliance | Laing distal myopathy | 160500 |
| hypertrophic cardiomyopathy 1 | Alliance | Cardiomyopathy, hypertrophic, 1 | 192600 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR000048 | IQ motif, EF-hand binding site |
| Domain | IPR001609 | Myosin head, motor domain |
| Domain | IPR002928 | Myosin tail |
| Domain | IPR004009 | Myosin, N-terminal, SH3-like |
| Homologous_superfamily | IPR008989 | Myosin S1 fragment, N-terminal |
| Homologous_superfamily | IPR014751 | DNA repair protein XRCC4-like, C-terminal |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Length | DNA repair protein XRCC4-like, C-terminal | IQ motif, EF-hand binding site | Kinesin motor domain superfamily | Myosin head, motor domain | Myosin, N-terminal, SH3-like | Myosin S1 fragment, N-terminal | Myosin tail | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QZW1
|
1938 |
Interactions and Pathways
No data available
Plasmids
No data available