header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990415-183
Gene Name: notch receptor 1b
Gene Symbol: notch1b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: etID309871.5 (1), wu:fc55e11

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including fin regeneration; nervous system development; and vasculature development. Predicted to localize to the plasma membrane and protein-containing complex. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic multipotent progenitor cell; nervous system; and trunk. Orthologous to human NOTCH1 (notch receptor 1).
Genome Resources: Alliance (1),  Gene:794892 (1),  Ensembl(GRCz11):ENSDARG00000052094 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1187 Point Mutation Unknown Splice Site ENU
sa11236 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26616 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26617 Point Mutation Unknown Splice Site ENU
    zf2046 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-notch1b 1
    CRISPR2-notch1b 1
    MO1-notch1b N/A 3
    MO2-notch1b N/A 12
    MO3-notch1b N/A 1
    MO4-notch1b N/A 3
    MO5-notch1b N/A 1
    MO6-notch1b N/A 3
    MO7-notch1b N/A 2
    DISEASE ASSOCIATED WITH notch1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Adams-Oliver syndrome Alliance Adams-Oliver syndrome 5 616028
    aortic valve disease 1 Alliance Aortic valve disease 1 109730
    DISEASE ASSOCIATED WITH notch1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal aorta development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 25)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA notch1b-202 (1)    Ensembl 7824
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM notch1b No data available
    MARKER RELATIONSHIPS
    notch1b Contained in: [BAC] DKEY-157G20 (order this), RP71-31M18 (1) (order this)
    notch1b Encodes: [EST] eu523 (1), fc55e11
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131302 (1) 7797 bp
    Genomic GenBank:BX119981 (1) 158974 bp
    Select Tool
    Polypeptide UniProtKB:A0PGH6 (1) 2465 aa
    Sequence Clusters UniGene:75825 (1)
    Sequence Information (all 24)
    ORTHOLOGY for notch1b ( Chr: 5 )
    CITATIONS (202)