Gene

notch1b

ID
ZDB-GENE-990415-183
Name
notch receptor 1b
Symbol
notch1b Nomenclature History
Previous Names
  • etID309871.5 (1)
  • wu:fc55e11
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable calcium ion binding activity and signaling receptor activity. Involved in Notch signaling pathway and hematopoietic stem cell differentiation. Acts upstream of or within several processes, including fin regeneration; nervous system development; and vasculature development. Predicted to be located in membrane and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic multipotent progenitor cell; nervous system; and trunk. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
164 figures from 109 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 12 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With notch1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Adams-Oliver syndrome Alliance Adams-Oliver syndrome 5 616028
aortic valve disease 1 Alliance Aortic valve disease 1 109730
Associated With notch1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000800 Notch domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR010660 Notch, NOD domain
Domain IPR011656 Notch, NODP domain
Domain IPR024600 Notch, C-terminal
Family IPR008297 Notch
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR035993 Notch-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Notch Notch, C-terminal Notch domain Notch-like domain superfamily Notch, NOD domain Notch, NODP domain
UniProtKB:A5WUN6 2436
UniProtKB:F1QCA7 2465
UniProtKB:O93616 683
UniProtKB:A0PGH6 2465
UniProtKB:O42372 638
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations