FIGURE

Fig. 5

ID

ZDB-FIG-081117-6

Publication

Aman et al., 2008 - Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Fgf Signaling Inhibits Wnt/β-Catenin Signaling via Induction of dkk1

(A and B) SU5402 treatment leads to ectopic induction of the Wnt/β-catenin signaling targets lef1 and axin2 in 36 hpf embryos.

(D–F) (D) dkk1 is a Fgf target, as it is highly upregulated in apc^mcr mutant primordia and is absent in (E) Fgf signaling-depleted WT, as well as in (F) Fgf signaling-depleted apc^mcr mutant primordia.

(G and H) Morpholino knockdown of dkk1 causes expansion of lef1 and axin2, similar to loss of Fgf signaling. The scale bar is equal to 40 μM.

Expression Data

Genes:	axin2 dkk1b lef1
Fish:	WT apc^hu745/hu745 WT + MO1-dkk1b
Condition:	chemical treatment: SU5402
Knockdown Reagent:	MO1-dkk1b
Anatomical Term:	posterior lateral line primordium
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	apc^hu745/hu745
Observed In:	posterior lateral line primordium
Stage:	Prim-25

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Cell, 15(5), Aman, A., and Piotrowski, T., Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression, 749-761, Copyright (2008) with permission from Elsevier. Full text @ Dev. Cell