ZFIN ID: ZDB-GENE-990714-26
Gene Name: lymphoid enhancer-binding factor 1
Gene Symbol: lef1    Nomenclature History

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Previous Name: etID310027.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in several processes, including animal organ development; fin development; and regulation of gene expression. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in ovarian cancer. Is expressed in several structures, including midbrain hindbrain boundary neural rod; nervous system; neural crest; pleuroperitoneal region; and trunk. Orthologous to human LEF1 (lymphoid enhancer binding factor 1).
Genome Resources: Alliance (1),  Gene:30701 (1),  Ensembl(GRCz11):ENSDARG00000031894 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013709Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021271Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021272Tg Transgenic Insertion Unknown Unknown DNA
    la021273Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021274Tg Transgenic Insertion Unknown Unknown DNA
    nl2 Insertion Unknown Frameshift ENU
    sa10902 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18709 Point Mutation Unknown Splice Site ENU
    sa32764 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39684 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • u767 Point Mutation Donor Splice Site of Intron 2 Splice Site ENU
    zd11 Small Deletion Exon 1 Unknown ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lef1 N/A 11
    MO2-lef1 N/A 10
    MO3-lef1 N/A 5
    MO4-lef1 N/A 2
    MO5-lef1 N/A 1
    DISEASE ASSOCIATED WITH lef1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Sebaceous tumors, somatic
    DISEASE ASSOCIATED WITH lef1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 38)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lef1-201 (1)    Ensembl 430
    lef1-202 (1)    Ensembl 2866
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-lef1 polyclonal Rabbit IHC, WB 4
    CONSTRUCTS WITH SEQUENCES FROM lef1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(lef1:TETAM2-2A-AmCyan) lef1 2AAmCyanTETAM2 Danio rerio 1 2
    MARKER RELATIONSHIPS
    lef1 Contained in: [BAC] DKEY-5K4 (1) (order this), DKEY-252L8 (1) (order this)
    lef1 Encodes: [cDNA] MGC:193547 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131426 (1) 2819 nt
    Genomic GenBank:CR391978 (1) 137171 nt
    Select Tool
    Polypeptide UniProtKB:Q9W7C0 (1) 365 aa
    Sequence Information (all 15)
    ORTHOLOGY for lef1 ( Chr: 1 )
    CITATIONS (197)