ZFIN ID: ZDB-GENE-990714-26
Gene Name: lymphoid enhancer-binding factor 1
Gene Symbol: lef1
Sequence Ontology ID : SO:0000704

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Previous Name: etID310027.1 (1)

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(Including Attributions)
Location: Chr: 1 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 88 figures from 56 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anatomical structure, cell, central nervous system, cranial neural crest cell (all 41) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la013709Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021271Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021272Tg Transgenic Insertion Unknown Unknown DNA
    la021273Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021274Tg Transgenic Insertion Unknown Unknown DNA
    nl2 Insertion Unknown Frameshift ENU
    sa10902 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa18709 Point Mutation Unknown Splice Site ENU
    sa32764 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39684 Point Mutation Unknown Splice Site ENU
    u767 Point Mutation Donor Splice Site of Intron 2 Splice Site ENU
    zd11 Small Deletion Exon 1 Unknown ZINC_FINGER_NUCLEASE
    Targeting reagents: MO1-lef1 (1), MO2-lef1 (1), MO3-lef1 (1), MO4-lef1 (1), MO5-lef1 (1)
    PHENOTYPE
    Data: 27 figures from 12 publications
    Observed in: anal fin, brain, canonical Wnt signaling pathway involved in neural crest cell differentiation, cartilage morphogenesis (all 50) expand
    DISEASE ASSOCIATED WITH lef1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Sebaceous tumors, somatic
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Wnt signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 62)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR009071 (1)
  • InterPro:IPR013558 (1)
  • InterPro:IPR024940 (1)
  • InterPro:IPR027397 (1)
  • InterPro:IPR028769 (1)
  • PROSITE:PS50118 (1)
  • Pfam:PF00505 (1)
  • Pfam:PF08347 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lef1-001 (1) 2866
    lef1-002 (1) 430
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Ab1-lef1 (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM lef1
    tg(lef1:tetam2-2a-amcyan)
    MARKER RELATIONSHIPS
    lef1Contained in: [BAC] DKEY-5K4 (1) (order this), DKEY-252L8 (1) (order this)
    lef1Encodes: [cDNA] MGC:193547 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131426 (1) 2819bp
    Genomic GenBank:CR391978 (1) 137171bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4II86 (1) 370aa
    Sequence Clusters UniGene:64686 (1)
    Sequence Information (all 16)
    OTHER lef1 GENE PAGES
  • Alliance (1)
  • Gene:30701 (1)
  • VEGA:OTTDARG00000019575 (1)
  • Ensembl(GRCz10):ENSDARG00000031894 (1)
  • ORTHOLOGY for lef1 (Chr: 1)
    CITATIONS (159)