|ZFIN ID: ZDB-PUB-081114-13|
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Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression
Aman, A., and Piotrowski, T.
|Source:||Developmental Cell 15(5): 749-761 (Journal)|
|Registered Authors:||Aman, Andy, Piotrowski, Tatjana|
|PubMed:||19000839 Full text @ Dev. Cell|
Aman, A., and Piotrowski, T. (2008) Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression. Developmental Cell. 15(5):749-761.
ABSTRACTCollective cell migration is a hallmark of embryonic morphogenesis and cancer metastases. However, the molecular mechanisms regulating coordinated cell migration remain poorly understood. A genetic dissection of this problem is afforded by the migrating lateral line primordium of the zebrafish. We report that interactions between Wnt/beta-catenin and Fgf signaling maintain primordium polarity by differential regulation of gene expression in the leading versus the trailing zone. Wnt/beta-catenin signaling in leader cells informs coordinated migration via differential regulation of the two chemokine receptors, cxcr4b and cxcr7b. These findings uncover a molecular mechanism whereby a migrating tissue maintains stable, polarized gene expression domains despite periodic loss of whole groups of cells. Our findings also bear significance for cancer biology. Although the Fgf, Wnt/beta-catenin, and chemokine signaling pathways are well known to be involved in cancer progression, these studies provide in vivo evidence that these pathways are functionally linked.