ZFIN All Figures, Zhang <i>et al.</i>, 2020

Fig. 1

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	DsRed2 EGFP mbpa mpz olig2 plp1a
Fish:	WT ck1Tg vu19Tg
Condition:	chemical treatment by environment: copper(2+)
Anatomical Terms:	spinal cord whole organism
Stage Range:	Long-pec to Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT ck1Tg vu19Tg
Condition:	chemical treatment by environment: copper(2+)
Observed In:	central nervous system axon central nervous system myelin sheath spinal cord whole organism
Stage Range:	Long-pec to Day 5

Phenotype details

Fig. 2

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	mbpa plp1a
Fish:	WT hoxb5b^hza5/hza5 WT + MO2-hoxb5b
Condition:	chemical treatment by environment: copper(2+)
Knockdown Reagent:	MO2-hoxb5b
Anatomical Terms:	spinal cord whole organism
Stage:	Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT hoxb5b^hza5/hza5 WT + MO2-hoxb5b vu19Tg + MO2-hoxb5b
Condition:	chemical treatment by environment: copper(2+)
Knockdown Reagent:	MO2-hoxb5b
Observed In:	brain central nervous system axon eye spinal cord trunk whole organism
Stage Range:	Long-pec to Day 4

Phenotype details

Fig. 3

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	DsRed2 hoxb5b mbpa plp1a
Fish:	WT vu19Tg
Conditions:	chemical treatment by environment: copper(2+) chemical treatment by environment: copper(2+)
Anatomical Terms:	central nervous system trunk
Stage Range:	Prim-5 to Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT vu19Tg
Conditions:	chemical treatment by environment: copper(2+) chemical treatment by environment: copper(2+)
Observed In:	central nervous system central nervous system axon trunk
Stage Range:	Prim-5 to Day 4

Phenotype details

Fig. 4

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	fam168a fam168b pou3f1
Fish:	WT
Condition:	chemical treatment by environment: copper(2+)
Anatomical Terms:	central nervous system whole organism
Stage Range:	Prim-5 to Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT
Condition:	chemical treatment by environment: copper(2+)
Observed In:	central nervous system whole organism
Stage Range:	Prim-5 to Day 4

Phenotype details

Fig. 5

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	fam168a fam168b mbpa plp1a
Fish:	WT fam168a^hza6/hza6 fam168b^hza8/hza8 WT + MO1-fam168a WT + MO1-fam168b WT + MO1-pou3f1
Knockdown Reagents:	MO1-fam168a MO1-fam168b MO1-pou3f1
Anatomical Terms:	brain central nervous system whole organism
Stage:	Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	fam168a^hza6/hza6 fam168b^hza8/hza8 WT + MO1-fam168a WT + MO1-fam168b WT + MO1-pou3f1
Knockdown Reagents:	MO1-fam168a MO1-fam168b MO1-pou3f1
Observed In:	central nervous system head whole organism
Stage Range:	Prim-5 to Day 4

Phenotype details

Fig. 6

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	fam168a fam168b hoxb5b mbpa pou3f1
Fish:	WT hoxb5b^hza5/hza5 WT + MO1-fam168a WT + MO1-fam168b WT + MO1-pou3f1 WT + MO2-hoxb5b WT + CRISPR1-fam168a + CRISPR1-fam168b + MO1-pou3f1 + MO2-hoxb5b fam168b^hza8/hza8; hoxb5b^hza5/hza5
Condition:	chemical treatment by environment: copper(2+)
Knockdown Reagents:	CRISPR1-fam168a CRISPR1-fam168b MO1-fam168a MO1-fam168b MO1-pou3f1 MO2-hoxb5b
Anatomical Terms:	brain central nervous system whole organism
Stage:	Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT WT + MO1-fam168a WT + MO1-fam168b WT + MO1-pou3f1 WT + MO2-hoxb5b WT + CRISPR1-fam168a + CRISPR1-fam168b + MO1-pou3f1 + MO2-hoxb5b fam168b^hza8/hza8; hoxb5b^hza5/hza5
Condition:	chemical treatment by environment: copper(2+)
Knockdown Reagents:	CRISPR1-fam168a CRISPR1-fam168b MO1-fam168a MO1-fam168b MO1-pou3f1 MO2-hoxb5b
Observed In:	central nervous system chordate embryonic development whole organism
Stage:	Day 4

Phenotype details

Fig. 7

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	axin2 dlc fam168a fam168b fzd7b hoxb5b mbpa mpz nkd1 notch1a plp1a pou3f1
Fish:	WT atp7b^hza7/hza7 cox17^hza3/hza3
Conditions:	chemical treatment by environment: copper(2+) chemical treatment by environment: copper(2+)
Anatomical Terms:	central nervous system whole organism
Stage:	Day 4

Expression / Labeling details

PHENOTYPE:

Fish:	WT atp7a^hza4/hza4 atp7b^hza7/hza7 cox17^hza3/hza3
Conditions:	chemical treatment by environment: copper(2+) chemical treatment by environment: copper(2+)
Observed In:	central nervous system whole organism
Stage:	Day 4

Phenotype details

Acknowledgments

Full text @ BBA Gene Regulatory Mechanisms

Zhang et al., 2020

ZDB-PUB-200804-7
PMID:32745624

Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation

Zhang et al., 2020 ZDB-PUB-200804-7 PMID:32745624

Copper Stress Induces Zebrafish Central Neural System Myelin Defects via WNT/NOTCH-hoxb5b Signaling and pou3f1/fam168a/fam168b DNA Methylation

Zhang et al., 2020

ZDB-PUB-200804-7
PMID:32745624