ZFIN ID: ZDB-GENE-001202-1
Gene Name: proteolipid protein 1a
Gene Symbol: plp1a    Nomenclature History

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Previous Names: plp1, DM20 (1), DMalpha1 (1), etID60288.14 (1), wu:fc27f01 (1), wu:fj36d03 (1), wu:fj42d08 (1), zgc:110499

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Involved in myelination. Predicted to localize to the integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Is expressed in central nervous system; glial cell; and neural tube. Orthologous to human PLP1 (proteolipid protein 1).
Genome Resources: Alliance (1),  Gene:64264 (1),  Ensembl(GRCz11):ENSDARG00000103732 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42372 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42373 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH plp1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 2 Alliance Spastic paraplegia 2, X-linked 312920
    Pelizaeus-Merzbacher disease Alliance Pelizaeus-Merzbacher disease 312080
    DISEASE ASSOCIATED WITH plp1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process myelination (more)
    Cellular Component integral component of membrane (more)
    Molecular Function molecular_function (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001614 Myelin proteolipid protein PLP
    Conserved_site IPR018237 Myelin proteolipid protein PLP, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA plp1a-201 (1)    Ensembl 4964
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM plp1a No data available
    MARKER RELATIONSHIPS
    plp1a Contained in: [BAC] DKEY-27I16 (1) (order this), DKEY-169H1 (1) (order this)
    plp1a Encodes: [EST] fc27f01 (1), fj42d08 (1)
    [cDNA] MGC:110499 (1), MGC:192273 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_175576 (1) 4574 bp
    Genomic GenBank:CR753843 (1) 112358 bp
    Select Tool
    Polypeptide UniProtKB:Q8UUT6 (1) 245 aa
    Sequence Information (all 19)
    ORTHOLOGY for plp1a ( Chr: 14 )
    CITATIONS (53)