Gene

plp1a

ID
ZDB-GENE-001202-1
Name
proteolipid protein 1a
Symbol
plp1a Nomenclature History
Previous Names
  • plp1
  • DM20 (1)
  • DMalpha1 (1)
  • etID60288.14 (1)
  • wu:fc27f01 (1)
  • wu:fj36d03 (1)
  • wu:fj42d08 (1)
  • zgc:110499
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to be a structural constituent of myelin sheath. Involved in myelination. Predicted to localize to integral component of membrane; myelin sheath; and plasma membrane. Is expressed in central nervous system; glial cell; and neural tube. Human ortholog(s) of this gene implicated in Pelizaeus-Merzbacher disease and hereditary spastic paraplegia 2. Orthologous to human PLP1 (proteolipid protein 1).
Genome Resources
Note
None
Expression
All Expression Data
40 figures from 23 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With plp1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spastic paraplegia 2 Alliance Spastic paraplegia 2, X-linked 312920
Pelizaeus-Merzbacher disease Alliance Pelizaeus-Merzbacher disease 312080
Associated With plp1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018237 Myelin proteolipid protein PLP, conserved site
Family IPR001614 Myelin proteolipid protein PLP
Domain Details Per Protein
Protein Length Myelin proteolipid protein PLP Myelin proteolipid protein PLP, conserved site
UniProtKB:Q8UUT6 245
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations