Gene

hoxb5b

ID

ZDB-GENE-000823-6

Name

homeobox B5b

Symbol

hoxb5b Nomenclature History

Previous Names

hoxa5
hoxzf54
etID309875.12 (1)
hoxb5-like
id:ibd2566 (1)
z-2
ZF-54
zgc:101134

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in brain development; cardioblast differentiation; and cell fate specification. Predicted to localize to nucleus. Is expressed in several structures, including mesoderm; nervous system; otic vesicle; pharyngeal arch; and pronephric duct. Orthologous to human HOXB5 (homeobox B5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hoxb5b Human Ortholog

No data available

Associated With hoxb5b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001827	Homeobox protein, antennapedia type, conserved site
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeodomain
Domain	IPR020479	Homeodomain, metazoa
Family	IPR017995	Homeobox protein, antennapedia type
Family	IPR050296	Antennapedia-type homeobox
Homologous_superfamily	IPR009057	Homedomain-like superfamily

Domain Details Per Protein

Protein	Length	Antennapedia-type homeobox	Homedomain-like superfamily	Homeobox, conserved site	Homeobox protein, antennapedia type	Homeobox protein, antennapedia type, conserved site	Homeodomain	Homeodomain, metazoa
UniProtKB:A0A0R4I9D0 InterPro	276
UniProtKB:P09013 InterPro	276

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	hoxb5b-201 (1) Ensembl	Ensembl		1,626 nt	Select Tool ZFIN BLAST
mRNA	ottdart00000001797 (1)	Havana		1,356 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations