ZFIN

ZFIN ID: ZDB-GENE-040702-5

ZFIN ID: ZDB-GENE-040702-5

CITATIONS (78 total)

Gene Name:	potassium voltage-gated channel, subfamily H (eag-related), member 6a
Gene Symbol:	kcnh6a

Chen, Y., Jia, J., Zhao, Q., Zhang, Y., Huang, B., Wang, L., Tian, J., Huang, C., Li, M., Li, X. (2022) Novel Loss-of-Function Variant in HNF1a Induces β-Cell Dysfunction through Endoplasmic Reticulum Stress. International Journal of Molecular Sciences. 23(21):

Cornean, A., Gierten, J., Welz, B., Mateo, J.L., Thumberger, T., Wittbrodt, J. (2022) Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction. eLIFE. 11:

Duong, T., Rose, R., Blazeski, A., Fine, N., Woods, C.E., Thole, J.F., Sotoodehnia, N., Soliman, E.Z., Tung, L., McCallion, A.S., Arking, D.E. (2021) Development and optimization of an in vivo electrocardiogram recording method and analysis program for adult zebrafish. Disease models & mechanisms. 14(8):

Marchal, G.A., Jouni, M., Chiang, D.Y., Pérez-Hernández Duran, M., Podliesna, S., Yu, N., Casini, S., Potet, F., Veerman, C.C., Klerk, M., Lodder, E.M., Mengarelli, I., Guan, K., Vanoye, C.G., Rothenberg, E., Charpentier, F., Redon, R., George, A., Verkerk, A.O., Bezzina, C.R., MacRae, C.A., Burridge, P., Delmar, M., Galjart, N.J., Portero, V., Remme, C.A. (2021) Targeting the Microtubule EB1-CLASP2 Complex Modulates Na_V1.5 at Intercalated Discs. Circulation research. 129(3):349-365

Sharma, S., Rana, A.K., Sharma, A., Singh, D. (2021) Inhibition of Mammalian Target of Rapamycin Attenuates Recurrent Seizures Associated Cardiac Damage in a Zebrafish Kindling Model of Chronic Epilepsy. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 17(1-2):334-349

Cunha, V., Vogs, C., Le Bihanic, F., Dreij, K. (2020) Mixture effects of oxygenated PAHs and benzo[a]pyrene on cardiovascular development and function in zebrafish embryos. Environment International. 143:105913

Hoshijima, K., Jurynec, M.J., Klatt Shaw, D., Jacobi, A.M., Behlke, M.A., Grunwald, D.J. (2019) Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. Developmental Cell. 51(5):645-657.e4

Hull, C.M., Genge, C.E., Hobbs, Y., Rayani, K., Lin, E., Gunawan, M., Shafaattalab, S., Tibbits, G.F., Claydon, T.W. (2019) Investigating the utility of adult zebrafish ex vivo whole hearts to pharmacologically screen hERG channel activator compounds. American journal of physiology. Regulatory, integrative and comparative physiology. 317(6):R921-R931

Li, X., Xiong, D., Ding, G., Fan, Y., Ma, X., Wang, C., Xiong, Y., Jiang, X. (2019) Exposure to water-accommodated fractions of two different crude oils alters morphology, cardiac function and swim bladder development in early-life stages of zebrafish. Chemosphere. 235:423-433

Tsata, V., Kroehne, V., Reinhardt, S., El-Armouche, A., Brand, M., Wagner, M., Reimer, M.M. (2019) Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Frontiers in Cellular Neuroscience. 13:102

Xu, S., Liu, C., Xie, F., Tian, L., Manno, S.H., Manno, F.A.M., Fallah, S., Pelster, B., Tse, G., Cheng, S.H. (2019) Excessive inflammation impairs heart regeneration in zebrafish breakdance mutant after cryoinjury. Fish & shellfish immunology. 89:117-126

Liu, L., Zhu, H., Yan, Y., Lv, P., Wu, W. (2018) Toxicity Evaluation and Biomarker Selection with Validated Reference Gene in Embryonic Zebrafish Exposed to Mitoxantrone. International Journal of Molecular Sciences. 19(11)

Tanaka, Y., Hayashi, K., Fujino, N., Konno, T., Tada, H., Nakanishi, C., Hodatsu, A., Tsuda, T., Nagata, Y., Teramoto, R., Yoshida, S., Nomura, A., Kawashiri, M.A., Yamagishi, M. (2018) Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography. Heart and vessels. 34(1):159-166

Bezzerides, V.J., Zhang, A., Xiao, L., Simonson, B., Khedkar, S.A., Baba, S., Ottaviano, F., Lynch, S., Hessler, K., Rigby, A.C., Milan, D., Das, S., Rosenzweig, A. (2017) Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders. Scientific Reports. 7:346

Slade, L., Cowie, A., Martynuik, C.J., Kienesberger, P.C., Pulinilkunnil, T. (2017) Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio).. The Journal of pharmacology and experimental therapeutics. 361(3):375-385

Benz, A., Kossack, M., Auth, D., Seyler, C., Zitron, E., Juergensen, L., Katus, H.A., Hassel, D. (2016) miR-19b Regulates Ventricular Action Potential Duration in Zebrafish. Scientific Reports. 6:36033

Bobesh, K.A., Renuka, J., Srilakshmi, R.R., Yellanki, S., Kulkarni, P., Yogeeswari, P., Sriram, D. (2016) Replacement of cardiotoxic aminopiperidine linker with piperazine moiety reduces cardiotoxicity? Mycobacterium tuberculosis novel bacterial topoisomerase inhibitors. Bioorganic & Medicinal Chemistry. 24:42-52

Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37

Hoshijima, K., Jurynec, M.J., Grunwald, D.J. (2016) Precise Editing of the Zebrafish Genome Made Simple and Efficient. Developmental Cell. 36:654-67

Jeankumar, V.U., Saxena, S., Vats, R., Reshma, R.S., Janupally, R., Kulkarni, P., Yogeeswari, P., Sriram, D. (2016) Structure-Guided Discovery of Antitubercular Agents That Target the Gyrase ATPase Domain. ChemMedChem. 11:539-48

Liu, C.C., Li, L., Lam, Y.W., Siu, C.W., Cheng, S.H. (2016) Improvement of surface ECG recording in adult zebrafish reveals that the value of this model exceeds our expectation. Scientific Reports. 6:25073

Medapi, B., Meda, N., Kulkarni, P., Yogeeswari, P., Sriram, D. (2016) Development of acridine derivatives as selective Mycobacterium tuberculosis DNA gyrase inhibitors. Bioorganic & Medicinal Chemistry. 24:877-85

Orr, N., Arnaout, R., Gula, L.J., Spears, D.A., Leong-Sit, P., Li, Q., Tarhuni, W., Reischauer, S., Chauhan, V.S., Borkovich, M., Uppal, S., Adler, A., Coughlin, S.R., Stainier, D.Y., Gollob, M.H. (2016) A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation. Nature communications. 7:11303

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Jeankumar, V.U., Kotagiri, S., Janupally, R., Suryadevara, P., Sridevi, J.P., Medishetti, R., Kulkarni, P., Yogeeswari, P., Sriram, D. (2015) Exploring the gyrase ATPase domain for tailoring newer anti-tubercular drugs: hit to lead optimization of a novel class of thiazole inhibitors. Bioorganic & Medicinal Chemistry. 23:588-601

Jeankumar, V.U., Reshma, R.S., Janupally, R., Saxena, S., Sridevi, J.P., Medapi, B., Kulkarni, P., Yogeeswari, P., Sriram, D. (2015) Enabling the (3 + 2) cycloaddition reaction in assembling newer anti-tubercular lead acting through the inhibition of the gyrase ATPase domain: lead optimization and structure activity profiling. Organic & biomolecular chemistry. 13:2423-31

Kannan, R.R., Iniyan, A.M., Vincent, S.G. (2015) Chemical genetic effects of Sargassum wightii during embryonic development in zebrafish. Indian journal of pharmacology. 47:195-8

Medapi, B., Renuka, J., Saxena, S., Sridevi, J.P., Medishetti, R., Kulkarni, P., Yogeeswari, P., Sriram, D. (2015) Design and synthesis of novel quinoline-aminopiperidine hybrid analogues as Mycobacterium tuberculosis DNA gyraseB inhibitors. Bioorganic & Medicinal Chemistry. 23(9):2062-78

Azuaje, F.J. (2014) Selecting biologically informative genes in co-expression networks with a centrality score. Biology Direct. 9:12

Jeankumar, V.U., Renuka, J., Pulla, V.K., Soni, V., Sridevi, J.P., Suryadevara, P., Shravan, M., Medishetti, R., Kulkarni, P., Yogeeswari, P., and Sriram, D. (2014) Development of novel N-linked aminopiperidine-based mycobacterial DNA gyrase B inhibitors: Scaffold hopping from known antibacterial leads. International Journal of Antimicrobial Agents. 43(3):269-78

Chaudhari, G.H., Chennubhotla, K.S., Chatti, K., and Kulkarni, P. (2013) Optimization of the adult zebrafish ECG method for assessment of drug-induced QTc prolongation. Journal of Pharmacological and Toxicological Methods. 67(2):115-120

Jou, C.J., Barnett, S.M., Bian, J.T., Weng, H.C., Sheng, X., and Tristani-Firouzi, M. (2013) An In Vivo Cardiac Assay to Determine the Functional Consequences of Putative Long QT Syndrome Mutations. Circulation research. 112(5):826-830

Novodvorsky, P., da Costa, M.M.J., and Chico, T.J.A. (2013) Zebrafish-based small molecule screens for novel cardiovascular drugs. Drug Discovery Today: Technologies. 10(1):e109-e114

Samson, S.C., Ferrer, T., Jou, C.J., Sachse, F.B., Shankaran, S.S., Shaw, R.M., Chi, N.C., Tristani-Firouzi, M., and Yost, H.J. (2013) 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biology. 11(12):e1001727

Leong, I.U., Lan, C.C., Skinner, J.R., Shelling, A.N., and Love, D.R. (2012) In Vivo Testing of MicroRNA-Mediated Gene Knockdown in Zebrafish. Journal of biomedicine & biotechnology. 2012:350352

Stengel, R., Rivera-Milla, E., Sahoo, N., Ebert, C., Bollig, F., Heinemann, S.H., Schonherr, R., and Englert, C. (2012) Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. The Journal of biological chemistry. 287(42):35565-35575

Meder, B., Scholz, E.P., Hassel, D., Wolff, C., Just, S., Berger, I.M., Patzel, E., Karle, C., Katus, H.A., and Rottbauer, W. (2011) Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish. Biochemical and Biophysical Research Communications. 408(2):218-224

Peal, D.S., Mills, R.W., Lynch, S.N., Mosley, J.M., Lim, E., Ellinor, P.T., January, C.T., Peterson, R.T., and Milan, D.J. (2011) Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen. Circulation. 123(1):23-30

Zhang, Y.H., Colenso, C.K., Sessions, R.B., Dempsey, C.E., and Hancox, J.C. (2011) The hERG K(+) channel S4 domain L532P mutation: Characterization at 37°C. Biomembranes. 1808(10):2477-87

Chopra, S.S., Stroud, D.M., Watanabe, H., Bennett, J.S., Burns, C.G., Wells, K.S., Yang, T., Zhong, T.P., and Roden, D.M. (2010) Voltage-Gated Sodium Channels Are Required for Heart Development in Zebrafish. Circulation research. 106(8):1342-1350

Kopp, R., Schwerte, T., Egg, M., Sandbichler, A.M., Egger, B., and Pelster, B. (2010) Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. Physiological Genomics. 42(1):8-23

Leong, I.U., Skinner, J.R., Shelling, A.N., and Love, D.R. (2010) Identification and expression analysis of kcnh2 genes in the zebrafish. Biochemical and Biophysical Research Communications. 396(4):817-824

Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559

Scholz, E.P., Niemer, N., Hassel, D., Zitron, E., Bürgers, H.F., Bloehs, R., Seyler, C., Scherer, D., Thomas, D., Kathöfer, S., Katus, H.A., Rottbauer, W.A., and Karle, C.A. (2009) Biophysical properties of zebrafish ether-à-go-go related gene potassium channels. Biochemical and Biophysical Research Communications. 381(2):159-164

Chi, N.C., Shaw, R.M., Jungblut, B., Huisken, J., Ferrer, T., Arnaout, R., Scott, I., Beis, D., Xiao, T., Baier, H., Jan, L.Y., Tristani-Firouzi, M., and Stainier, D.Y. (2008) Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System. PLoS Biology. 6(5):e109

Hassel, D., Scholz, E.P., Trano, N., Friedrich, O., Just, S., Meder, B., Weiss, D.L., Zitron, E., Marquart, S., Vogel, B., Karle, C.A., Seemann, G., Fishman, M.C., Katus, H.A., and Rottbauer, W. (2008) Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants. Circulation. 117(7):866-875

Arnaout, R., Ferrer, T., Huisken, J., Spitzer, K., Stainier, D.Y., Tristani-Firouzi, M., and Chi, N.C. (2007) Zebrafish model for human long QT syndrome. Proceedings of the National Academy of Sciences of the United States of America. 104(27):11316-11321

Brown, S.B., Tucker, C.S., Ford, C., Lee, Y., Dunbar, D.R., and Mullins, J.J. (2007) Class III antiarrhythmic methanesulfonanilides inhibit leukocyte recruitment in zebrafish. Journal of Leukocyte Biology. 82(1):79-84

Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development (Cambridge, England). 132(18):4193-4204

Kopp, R., Schwerte, T., and Pelster, B. (2005) Cardiac performance in the zebrafish breakdance mutant. The Journal of experimental biology. 208(Pt 11):2123-2134

Langheinrich, U., Vacun, G., and Wagner, T. (2003) Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. Toxicology and applied pharmacology. 193(3):370-382

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302

Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Malicki, J., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J., and Boggs, C. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development (Cambridge, England). 123:37-46

Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36

Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Driever, W., and Fishman, M.C. (1996) Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (Cambridge, England). 123:285-292

Additional Citations (22):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

Geisler, R. (2013) Importation of Tübingen internal allele names. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

Phenotype Annotation (1994-2006) (2006) Mutant Data Curated from Older Literature. ZFIN Historical Data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Submission and Curation of Mutant and Transgenic Lines. ZFIN Direct Data Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.