Gene

kcnh6a

ID
ZDB-GENE-040702-5
Name
potassium voltage-gated channel, subfamily H (eag-related), member 6a
Symbol
kcnh6a Nomenclature History
Previous Names
  • kcnh2
  • kcnh6
  • bre
  • breakdance
  • erg
  • ether-a-go-go-related (1)
  • reg
  • reggae (1)
  • silent ventricle (1)
  • unm s213
  • zerg-3 (1)
  • zerg (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Exhibits voltage-gated potassium channel activity. Involved in several processes, including heart contraction; membrane repolarization during cardiac muscle cell action potential; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to localize to integral component of plasma membrane. Used to study long QT syndrome and short QT syndrome. Is expressed in several structures, including cardiovascular system; digestive system; gill; immune system; and muscle. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
30 figures from 14 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With kcnh6a Human Ortholog
No data available
Associated With kcnh6a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR005821 Ion transport domain
Family IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
Family IPR003967 Potassium channel, voltage-dependent, ERG
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR018490 Cyclic nucleotide-binding-like
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Homologous_superfamily IPR035965 PAS domain superfamily
Domain Details Per Protein
Protein Length Cyclic nucleotide-binding domain Cyclic nucleotide-binding-like Ion transport domain PAS domain PAS domain superfamily Potassium channel, voltage-dependent, EAG/ELK/ERG Potassium channel, voltage-dependent, ERG RmlC-like jelly roll fold Voltage-dependent channel domain superfamily
UniProtKB:B3DJX4 1186
UniProtKB:E9QJ94 1098
UniProtKB:Q8JH78 1186
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Deleted orthology to KCNH2 from Lagenheinrich et al (2003) based on new orthology information in Leong et al (2010). Assigned orthology to KCNH6 based on synteny presented in Leong et al.
Citations