ZFIN ID: ZDB-GENE-040702-5
Gene Name: potassium voltage-gated channel, subfamily H (eag-related), member 6a
Gene Symbol: kcnh6a    Nomenclature History

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Previous Names: kcnh2, kcnh6, bre, breakdance, erg, ether-a-go-go-related (1), reg, reggae (1), silent ventricle (1), unm s213, zerg-3 (1), zerg (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits voltage-gated potassium channel activity. Involved in several processes, including heart contraction; membrane repolarization during cardiac muscle cell action potential; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; gill; immune system; and muscle. Used to study long QT syndrome and short QT syndrome. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6).
Genome Resources: Alliance (1),  Gene:405763 (1),  Ensembl(GRCz11):ENSDARG00000001803 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m230 Point Mutation Exon 8 Missense ENU
s213 Point Mutation Unknown Missense ENU
s290 Point Mutation Unknown Missense ENU
sa17340 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tb218 Point Mutation Exon 2 Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • z46Tg Transgenic Insertion Unknown Unknown TALEN
    z47 Small Deletion Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kcnh6a
    1
    MO1-kcnh6a N/A 4
    MO2-kcnh6a N/A 4
    MO3-kcnh6a N/A 3
    MO4-kcnh6a N/A 2
    TALEN1-kcnh6a 1
    DISEASE ASSOCIATED WITH kcnh6a HUMAN ORTHOLOG No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kcnh6a-202 (1)    Ensembl 4931
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kcnh6a No data available
    MARKER RELATIONSHIPS
    kcnh6a Contained in: [BAC] DKEY-15N1 (1) (order this), DKEY-194J22 (1) (order this)
    kcnh6a Encodes: [cDNA] MGC:194341 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212837 (1) 4592 nt
    Genomic GenBank:BX324157 (1) 272769 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DJX4 (1) 1186 aa
    Sequence Information (all 21)
    ORTHOLOGY for kcnh6a ( Chr: 3 )
    CITATIONS (68)