ZFIN

ZFIN ID: ZDB-GENE-040426-1042

ZFIN ID: ZDB-GENE-040426-1042

CITATIONS (81 total)

Gene Name:	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Gene Symbol:	hmgcs1

Bhattacharya, D., Kaushal, S., Chakraborty, B., Raha, A., Dutta, T., Shekhar, H., Koner, A.L., Kumar, S., Ramachandran, R., Kaur Dhanjal, J., Minocha, S. (2025) Zebrafish model of palmitic acid induced MAFLD recapitulates pathways conserved in mice and humans. Scientific Reports. 15:3334333343

Luo, J., Tao, B., Chen, J., Song, Y., Hu, W. (2025) General transcription factor IIIAa regulates the transcription of somatic 5S rRNA and influences embryonic organ development in zebrafish. Marine life science & technology. 8:688168-81

Zimmerman, N., Marta, A., Baker, C., Korade, Z., Mirnics, K., Shibata, A. (2025) Investigating Psychopharmaceutical Effects on Early Vertebrate Development Using a Zebrafish Model System. Journal of developmental biology. 13:

Dofash, L.N.H., Miles, L.B., Saito, Y., Rivas, E., Calcinotto, V., Oveissi, S., Serrano, R.J., Templin, R., Ramm, G., Rodger, A., Haywood, J., Ingley, E., Clayton, J.S., Taylor, R.L., Folland, C.L., Groth, D., Hock, D.H., Stroud, D.A., Gorokhova, S., Donkervoort, S., Bönnemann, C.G., Sud, M., VanNoy, G.E., Mangilog, B.E., Pais, L., O'Donnell-Luria, A., Madruga-Garrido, M., Scala, M., Fiorillo, C., Baratto, S., Traverso, M., Malfatti, E., Bruno, C., Zara, F., Paradas, C., Ogata, K., Nishino, I., Laing, N.G., Bryson-Richardson, R.J., Cabrera-Serrano, M., Ravenscroft, G. (2024) HMGCS1 variants cause rigid spine syndrome amenable to mevalonic acid treatment in an animal model. Brain : a journal of neurology. :

Kim, M., So, J., Shin, D. (2023) PPARα activation promotes liver progenitor cell-mediated liver regeneration by suppressing YAP signaling in zebrafish. Scientific Reports. 13:1831218312

Williams, M.B., Green, G.B., Palmer, J.W., Fay, C.X., Chehade, S.B., Lawrence, A.L., Barry, R.J., Powell, M.L., Harris, M.L., Watts, S.A. (2023) Replacement of Dietary Fish Protein with Bacterial Protein Results in Decreased Adiposity Coupled with Liver Gene Expression Changes in Female Danio rerio. Current developments in nutrition. 8:102057102057

Zhang, A.N., Huang, C., Yan, L., Liu, X., Wang, F., Zhang, Z., Li, L., Zhang, C., Zhang, Q. (2023) Metabolic regulation and antihyperglycemic properties of diet-derived PGG through transcriptomic and metabolomic profiling. Food & function. 14(12):5620-5630

Zhu, Y., Hu, J., Zeng, S., Gao, M., Guo, S., Wang, M., Hong, Y., Zhao, G. (2023) L-selenomethionine affects liver development and glucolipid metabolism by inhibiting autophagy in zebrafish embryos. Ecotoxicology and environmental safety. 252:114589114589

Chen, S., Ye, W., Clements, K.D., Zan, Z., Zhao, W., Zou, H., Wang, G., Wu, S. (2022) Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. International Journal of Molecular Sciences. 24(1):

Dai, W., Wang, K., Zhen, X., Huang, Z., Liu, L. (2022) Magnesium isoglycyrrhizinate attenuates acute alcohol-induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress. Nutrition & metabolism. 19:23

Gao, G., Guo, S., Zhang, Q., Zhang, H., Zhang, C., Peng, G. (2022) Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles. eLIFE. 11:

Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):

Li, C., Wu, Y., Li, H., Wang, H., Liu, J.X. (2022) Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Fish physiology and biochemistry. 48(6):1571-1586

Singh, M.K., Yadav, R., Bhaskar, A.K., Sengupta, S., Sachidanandan, C. (2022) A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(1):159246

Xu, Y., Tian, J., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J., Li, M. (2022) Knockout of Nur77 Leads to Amino Acid, Lipid, and Glucose Metabolism Disorders in Zebrafish. Frontiers in endocrinology. 13:864631

Kong, Y., Li, Y., Dai, Z.R., Qin, M., Fan, H.L., Hao, J.G., Zhang, C.X., Zhong, Q.P., Qi, C., Wang, P. (2021) Glycosaminoglycan from Ostrea rivularis attenuates hyperlipidemia and regulates gut microbiota in high-cholesterol diet-fed zebrafish. Food science & nutrition. 9:5198-5210

Zhang, X.Y., Liu, Y.H., Liu, D.Z., Xu, J.Y., Zhang, Q. (2021) Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics. Pharmaceuticals (Basel, Switzerland). 14(7):

Zhao, G., Zhu, Y., Hu, J., Gao, M., Hong, Y. (2021) l-selenomethionine induces zebrafish embryo cardiovascular defects via down-regulating expression of lrp2b. Chemosphere. 290:133351

Castro, V.L., Reyes-Nava, N.G., Sanchez, B.B., Gonzalez, C.G., Paz, D., Quintana, A.M. (2020) Activation of WNT signaling restores the facial deficits in a zebrafish with defects in cholesterol metabolism. Genesis (New York, N.Y. : 2000). 58(12):e23397

Mi, X., Li, Z., Yan, J., Li, Y., Zheng, J., Zhaung, Z., Yang, W., Gong, L., Shi, J. (2020) Activation of HIF-1 signaling ameliorates liver steatosis in zebrafish atp7b deficiency (Wilson's disease) models. Biochimica et biophysica acta. Molecular basis of disease. 1866(10):165842

Wu, S.Y., Yang, W.Y., Cheng, C.C., Lin, K.H., Sampurna, B.P., Chan, S.M., Yuh, C.H. (2020) Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. Clinical and translational medicine. 10:e252

Zhang, D., Lin, W., Liu, Y., Guo, H., Wang, L., Yang, L., Li, L., Li, D., Tang, R. (2020) Chronic Microcystin-LR Exposure Induces Abnormal Lipid Metabolism via Endoplasmic Reticulum Stress in Male Zebrafish. toxins. 12(2):

Zhang, J., Qian, L., Wang, C., Teng, M., Duan, M., Chen, X., Li, X., Wang, C. (2020) UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Environmental pollution (Barking, Essex : 1987). 266:115310

Faught, E., Vijayan, M.M. (2019) Postnatal triglyceride accumulation is regulated by the mineralocorticoid receptor under basal and stress conditions. The Journal of physiology. 597(19):4927-4941

Gu, Q., Yang, X., Lv, J., Zhang, J., Xia, B., Kim, J.D., Wang, R., Xiong, F., Meng, S., Clements, T.P., Tandon, B., Wagner, D.S., Diaz, M.F., Wenzel, P.L., Miller, Y.I., Traver, D., Cooke, J.P., Li, W., Zon, L.I., Chen, K., Bai, Y., Fang, L. (2019) AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science (New York, N.Y.). 363:1085-1088

Hernandez, J.A., Castro, V.L., Reyes-Nava, N., Montes, L.P., Quintana, A.M. (2019) Mutations in the zebrafish hmgcs1 gene reveal a novel function for isoprenoids during red blood cell development. Blood advances. 3:1244-1254

Rau, A., Dhara, S.P., Udvadia, A.J., Auer, P.L. (2019) Regeneration Rosetta: An Interactive Web Application To Explore Regeneration-Associated Gene Expression and Chromatin Accessibility. G3 (Bethesda). 9(12):3953-3959

Wang, H., Lin, C., Yao, J., Shi, H., Zhang, C., Wei, Q., Lu, Y., Chen, Z., Xing, G., Cao, X. (2019) Deletion of OSBPL2 in auditory cells increases cholesterol biosynthesis and drives reactive oxygen species production by inhibiting AMPK activity. Cell Death & Disease. 10:627

Porseryd, T., Volkova, K., Reyhanian Caspillo, N., Källman, T., Dinnetz, P., Porsh Hällström, I. (2017) Persistent Effects of Developmental Exposure to 17α-Ethinylestradiol on the Zebrafish (Danio rerio) Brain Transcriptome and Behavior.. Frontiers in behavioral neuroscience. 11:69

Quintana, A.M., Hernandez, J.A., Gonzalez, C.G. (2017) Functional analysis of the zebrafish ortholog of HMGCS1 reveals independent functions for cholesterol and isoprenoids in craniofacial development. PLoS One. 12:e0180856

Zhou, Z., Zhong, W., Lin, H., Huang, P., Ma, N., Zhang, Y., Zhou, C., Lai, Y., Huang, S., Huang, S., Gao, L., Lv, Z. (2017) Hesperidin Protects against Acute Alcoholic Injury through Improving Lipid Metabolism and Cell Damage in Zebrafish Larvae. Evidence-based complementary and alternative medicine : eCAM. 2017:7282653

DeRossi, C., Vacaru, A., Rafiq, R., Cinaroglu, A., Imrie, D., Nayar, S., Baryshnikova, A., Milev, M.P., Stanga, D., Kadakia, D., Gao, N., Chu, J., Freeze, H.H., Lehrman, M.A., Sacher, M., Sadler, K.C. (2016) trappc11 is required for protein glycosylation in zebrafish and humans. Molecular biology of the cell. 27(8):1220-34

Mathews, E.S., Appel, B. (2016) Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:7628-39

Zeituni, E.M., Wilson, M.H., Zheng, X., Iglesias, P.A., Sepanski, M., Siddiqi, M.A., Anderson, J.L., Zheng, Y., Farber, S.A. (2016) Endoplasmic reticulum lipid flux influences enterocyte nuclear morphology and lipid-dependent transcriptional responses. The Journal of biological chemistry. 291(45):23804-23816

Zhang, C., Ellis, J.L., Yin, C. (2016) Inhibition of vascular endothelial growth factor signaling facilitates liver repair from acute ethanol-induced injury in zebrafish. Disease models & mechanisms. 9(11):1383-1396

Dai, W., Wang, K., Zheng, X., Chen, X., Zhang, W., Zhang, Y., Hou, J., Liu, L. (2015) High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs. Nutrition & metabolism. 12:42

Kearns, C.A., Ravanelli, A.M., Cooper, K., Appel, B. (2015) Fbxw7 Limits Myelination by Inhibiting mTOR Signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:14861-71

Li, P., Lahvic, J.L., Binder, V., Pugach, E.K., Riley, E.B., Tamplin, O.J., Panigrahy, D., Bowman, T.V., Barrett, F.G., Heffner, G.C., McKinney-Freeman, S., Schlaeger, T.M., Daley, G.Q., Zeldin, D.C., Zon, L.I. (2015) Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 523:468-71

Lin, J.N., Chang, L.L., Lai, C.H., Lin, K.J., Lin, M.F., Yang, C.H., Lin, H.H., Chen, Y.H. (2015) Development of an Animal Model for Alcoholic Liver Disease in Zebrafish. Zebrafish. 12(4):271-80

Wang, Y., Lu, Y., Zhang, Y., Ning, Z., Li, Y., Zhao, Q., Lu, H., Huang, R., Xia, X., Feng, Q., Liang, X., Liu, K., Zhang, L., Lu, T., Huang, T., Fan, D., Weng, Q., Zhu, C., Lu, Y., Li, W., Wen, Z., Zhou, C., Tian, Q., Kang, X., Shi, M., Zhang, W., Jang, S., Du, F., He, S., Liao, L., Li, Y., Gui, B., He, H., Ning, Z., Yang, C., He, L., Luo, L., Yang, R., Luo, Q., Liu, X., Li, S., Huang, W., Xiao, L., Lin, H., Han, B., Zhu, Z. (2015) The draft genome of the grass carp (Ctenopharyngodon idellus) provides insights into its evolution and vegetarian adaptation. Nature Genetics. 47(6):625-31

Chen, Z., Ballar, P., Fu, Y., Luo, J., Du, S., Fang, S. (2014) The E3 Ubiquitin Ligase gp78 Protects against ER Stress in Zebrafish Liver. Journal of genetics and genomics = Yi chuan xue bao. 41:357-68

Howarth, D.L., Lindtner, C., Vacaru, A.M., Sachidanandam, R., Tsedensodnom, O., Vasilkova, T., Buettner, C., Sadler, K.C. (2014) Activating transcription factor 6 is necessary and sufficient for alcoholic Fatty liver disease in zebrafish. PLoS Genetics. 10:e1004335

Lin, T.Y., Chou, C.F., Chung, H.Y., Chiang, C.Y., Li, C.H., Wu, J.L., Lin, H.J., Pai, T.W., Hu, C.H., Tzou, W.S. (2014) Hypoxia-Inducible Factor 2 Alpha Is Essential for Hepatic Outgrowth and Functions via the Regulation of leg1 Transcription in the Zebrafish Embryo. PLoS One. 9:e101980

Mathews, E.S., Mawdsley, D.J., Walker, M., Hines, J.H., Pozzoli, M., Appel, B. (2014) Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34:3402-12

Vacaru, A.M., Di Narzo, A.F., Howarth, D.L., Tsedensodnom, O., Imrie, D., Cinaroglu, A., Amin, S., Hao, K., Sadler, K.C. (2014) Molecularly defined unfolded protein response subclasses have distinct correlations with fatty liver disease in zebrafish. Disease models & mechanisms. 7:823-835

Tsedensodnom, O., Vacaru, A.M., Howarth, D.L., Yin, C., and Sadler, K.C. (2013) Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease. Disease models & mechanisms. 6(5):1213-26

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Zhao, Y., Qin, W., Zhang, J.P., Hu, Z.Y., Tong, J.W., Ding, C.B., Peng, Z.G., Zhao, L.X., Song, D.Q., and Jiang, J.D. (2013) HCV IRES-Mediated Core Expression in Zebrafish. PLoS One. 8(3):e56985

Hugo, S.E., Cruz-Garcia, L., Karanth, S., Anderson, R.M., Stainier, D.Y., and Schlegel, A. (2012) A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes & Development. 26(3):282-93

Choi, J., Mouillesseaux, K., Wang, Z., Fiji, H.D., Kinderman, S.S., Otto, G.W., Geisler, R., Kwon, O., and Chen, J.N. (2011) Aplexone targets the HMG-CoA reductase pathway and differentially regulates arteriovenous angiogenesis. Development (Cambridge, England). 138(6):1173-1181

Cinaroglu, A., Gao, C., Imrie, D., and Sadler, K.C. (2011) Atf6 plays protective and pathologic roles in fatty liver disease due to endoplasmic reticulum stress. Hepatology (Baltimore, Md.). 54(2):495-508

Zheng, D., Kille, P., Feeney, G.P., Cunningham, P., Handy, R.D., and Hogstrand, C. (2010) Dynamic transcriptomic profiles of zebrafish gills in response to zinc supplementation. BMC Genomics. 11:553

Zheng, D., Kille, P., Feeney, G.P., Cunningham, P., Handy, R.D., and Hogstrand, C. (2010) Dynamic transcriptomic profiles of zebrafish gills in response to zinc depletion. BMC Genomics. 11:548

Passeri, M.J., Cinaroglu, A., Gao, C., and Sadler, K.C. (2009) Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation. Hepatology (Baltimore, Md.). 49(2):443-452

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Hoffmann, J.L., Torontali, S.P., Thomason, R.G., Lee, D.M., Brill, J.L., Price, B.B., Carr, G.J., Versteeg, D.J. (2006) Hepatic gene expression profiling using Genechips in zebrafish exposed to 17alpha-ethynylestradiol. Aquatic toxicology (Amsterdam, Netherlands). 79(3):233-246

Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20

Weber, G.J., Choe, S.E., Dooley, K.A., Paffett-Lugassy, N.N., Zhou, Y., and Zon, L.I. (2005) Mutant-specific gene programs in the zebrafish. Blood. 106(2):521-530

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (22):

ZFIN Staff (2024) Association of Ensembl transcripts with ZFIN genes. Semi-automated Curation.

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

Zebrafish Nomenclature Committee (2003) Nomenclature Data Curation (2003-2010). Nomenclature Committee Submission.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Gene Ontology Annotation Through Association of Enzyme Commission numbers with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.