Gene

hmgcs1

ID
ZDB-GENE-040426-1042
Name
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Symbol
hmgcs1 Nomenclature History
Previous Names
  • zgc:56481 (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have hydroxymethylglutaryl-CoA synthase activity. Involved in animal organ development and oligodendrocyte development. Is expressed in several structures, including digestive system; immature eye; nervous system; pectoral fin musculature; and yolk syncytial layer. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
22 figures from 13 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hmgcs1 Human Ortholog
No data available
Associated With hmgcs1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active site
Domain IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
Domain IPR013746 Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain
Family IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
Homologous_superfamily IPR016039 Thiolase-like
Domain Details Per Protein
Protein Length Hydroxymethylglutaryl-CoA synthase, eukaryotic Hydroxymethylglutaryl-coenzyme A synthase, active site Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain Hydroxymethylglutaryl-coenzyme A synthase, N-terminal Thiolase-like
UniProtKB:A0A0R4IQG1 519
UniProtKB:A0A0R4IME3 141
UniProtKB:A0A0J9YJ34 283
UniProtKB:A0A0R4IJE0 201
UniProtKB:Q7ZWE2 508
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations