ZFIN

ZFIN ID: ZDB-GENE-030721-7

ZFIN ID: ZDB-GENE-030721-7

CITATIONS (72 total)

Gene Name:	myxovirus (influenza virus) resistance C
Gene Symbol:	mxc

Li, Z., Li, J., Li, Z., Song, Y., Wang, Y., Wang, C., Yuan, L., Xiao, W., Wang, J. (2024) Zebrafish mylipb attenuates antiviral innate immunity through two synergistic mechanisms targeting transcription factor irf3. PLoS pathogens. 20:e1012227e1012227

Yu, G., Yuan, L., Li, X., Zuo, M., Wang, R., Chen, M., Liu, Y., Liu, X., Xiao, W. (2024) Zebrafish phd1 enhances mavs-mediated antiviral responses in a hydroxylation-independent manner. Journal of virology. 98(9):e0103824

Li, Y.L., Gong, X.Y., Qu, Z.L., Zhao, X., Dan, C., Sun, H.Y., An, L.L., Gui, J.F., Zhang, Y.B. (2023) Zebrafish HERC7c Acts as an Inhibitor of Fish IFN Response. International Journal of Molecular Sciences. 24(5):

Ouyang, G., Liao, Q., Fan, S., Cai, X., Wang, J., Liu, X., Xiao, W. (2023) Zebrafish mavs Is Essential for Antiviral Innate Immunity. Journal of immunology (Baltimore, Md. : 1950). 210(9):1314-1323

Song, Y., Fan, S., Zhang, D., Li, J., Li, Z., Li, Z., Xiao, W., Wang, J. (2023) Zebrafish maoc1 Attenuates Spring Viremia of Carp Virus Propagation by Promoting Autophagy-Lysosome-Dependent Degradation of Viral Phosphoprotein. Journal of virology. 97(2):e0133822

Torraca, V., White, R.J., Sealy, I.M., Mazon-Moya, M., Duggan, G., Willis, A., Busch-Nentwich, E.M., Mostowy, S. (2023) Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri. Disease models & mechanisms. 17(1):

Yu, G.Q., Chen, M.J., Wang, Y.J., Liu, Y.Q., Zuo, M.Z., Zhang, Z.H., Li, G.X., Liu, B.Z., Li, M. (2023) Zebrafish spop promotes ubiquitination and degradation of mavs to suppress antiviral response via the lysosomal pathway. International journal of biological macromolecules. 256(Pt 2):128451

Chen, X., Fan, S., Zhu, C., Liao, Q., Tang, J., Yu, G., Cai, X., Ouyang, G., Xiao, W., Liu, X. (2022) Zebrafish sirt5 Negatively Regulates Antiviral Innate Immunity by Attenuating Phosphorylation and Ubiquitination of mavs. Journal of immunology (Baltimore, Md. : 1950). 209(6):1165-1172

Liang, H., Li, Y., Li, M., Zhou, W., Chen, J., Zhang, Z., Yang, Y., Ran, C., Zhou, Z. (2022) The effect and underlying mechanism of yeast β-glucan on antiviral resistance of zebrafish against spring viremia of carp virus infection. Frontiers in immunology. 13:1031962

Sanchez-Gonzalez, R., Koupourtidou, C., Lepko, T., Zambusi, A., Novoselc, K.T., Durovic, T., Aschenbroich, S., Schwarz, V., Breunig, C.T., Straka, H., Huttner, H.B., Irmler, M., Beckers, J., Wurst, W., Zwergal, A., Schauer, T., Straub, T., Czopka, T., Trümbach, D., Götz, M., Stricker, S.H., Ninkovic, J. (2022) Innate Immune Pathways Promote Oligodendrocyte Progenitor Cell Recruitment to the Injury Site in Adult Zebrafish Brain. Cells. 11(3):

Liao, Q., Ouyang, G., Zhu, J., Cai, X., Yu, G., Zhou, Z., Liu, X., Wang, J., Xiao, W. (2021) Zebrafish sirt7 Negatively Regulates Antiviral Responses by Attenuating Phosphorylation of irf3 and irf7 Independent of Its Enzymatic Activity. Journal of immunology (Baltimore, Md. : 1950). 207(12):3050-3059

Wu, X.M., Fang, H., Zhang, J., Bi, Y.H., Chang, M.X. (2021) Histone H2A Nuclear/Cytoplasmic Trafficking Is Essential for Negative Regulation of Antiviral Immune Response and Lysosomal Degradation of TBK1 and IRF3. Frontiers in immunology. 12:771277

Xie, M., Xie, Y., Li, Y., Zhou, W., Zhang, Z., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhou, Z. (2021) Stabilized fermentation product of Cetobacterium somerae improves gut and liver health and antiviral immunity of zebrafish. Fish & shellfish immunology. 120:56-66

Zhou, Z., Cai, X., Zhu, J., Li, Z., Yu, G., Liu, X., Ouyang, G., Xiao, W. (2021) Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 207(1):244-256

Zhu, J., Li, X., Sun, X., Zhou, Z., Cai, X., Liu, X., Wang, J., Xiao, W. (2021) Zebrafish prmt2 Attenuates Antiviral Innate Immunity by Targeting traf6. Journal of immunology (Baltimore, Md. : 1950). 207(10):2570-2580

Li, Z., Fan, S., Wang, J., Chen, X., Liao, Q., Liu, X., Ouyang, G., Cao, H., Xiao, W. (2020) Zebrafish F-box Protein fbxo3 Negatively Regulates Antiviral Response through Promoting K27-Linked Polyubiquitination of the Transcription Factors irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 205(7):1897-1908

Ouyang, G., Liao, Q., Zhang, D., Rong, F., Cai, X., Fan, S., Zhu, J., Wang, J., Liu, X., Liu, X., Xiao, W. (2020) Zebrafish NF-κB/p65 Is Required for Antiviral Responses. Journal of immunology (Baltimore, Md. : 1950). 204(11):3019-3029

Wu, X.M., Zhang, J., Li, P.W., Hu, Y.W., Cao, L., Ouyang, S., Bi, Y.H., Nie, P., Chang, M.X. (2020) NOD1 Promotes Antiviral Signaling by Binding Viral RNA and Regulating the Interaction of MDA5 and MAVS. Journal of immunology (Baltimore, Md. : 1950). 204(8):2216-2231

Xiong, F., Cao, L., Wu, X.M., Chang, M.X. (2020) The function of zebrafish gpbar1 in antiviral response and lipid metabolism. Developmental and comparative immunology. 116:103955

Yu, G., Li, X., Zhou, Z., Tang, J., Wang, J., Liu, X., Fan, S., Ouyang, G., Xiao, W. (2020) Zebrafish phd3 Negatively Regulates Antiviral Responses via Suppression of Irf7 Transactivity Independent of Its Prolyl Hydroxylase Activity. Journal of immunology (Baltimore, Md. : 1950). 205(4):1135-1146

Zhu, J., Liu, X., Cai, X., Ouyang, G., Fan, S., Wang, J., Xiao, W. (2020) Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:988-1000

Zhu, J., Liu, X., Cai, X., Ouyang, G., Zha, H., Zhou, Z., Liao, Q., Wang, J., Xiao, W. (2020) Zebrafish prmt3 negatively regulates antiviral responses. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(8):10212-10227

Cao, L., Wu, X.M., Nie, P., Chang, M.X. (2019) The negative regulation of piscine CD44c in viral and bacterial infection. Developmental and comparative immunology. 96:135-143

Yu, G., Liu, X., Tang, J., Xu, C., Ouyang, G., Xiao, W. (2019) Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in immunology. 10:1432

Hu, Y.W., Zhang, J., Wu, X.M., Cao, L., Nie, P., Chang, M.X. (2018) TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation. Frontiers in immunology. 9:84

Robertsen, B., Greiner Tollersrud, L., Jørgensen, L.G. (2018) Analysis of the Atlantic salmon genome reveals a cluster of Mx genes that respond more strongly to IFN gamma than to type I IFN. Developmental and comparative immunology. 90:80-89

Díaz-Pascual, F., Ortíz-Severín, J., Varas, M.A., Allende, M.L., Chávez, F.P. (2017) In vivo Host-Pathogen Interaction as Revealed by Global Proteomic Profiling of Zebrafish Larvae.. Frontiers in cellular and infection microbiology. 7:334

García-Valtanen, P., Martínez-López, A., López-Muñoz, A., Bello-Perez, M., Medina-Gali, R.M., Ortega-Villaizán, M.D., Varela, M., Figueras, A., Mulero, V., Novoa, B., Estepa, A., Coll, J. (2017) Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Frontiers in immunology. 8:121

Huang, C.J., Chou, C.M., Lien, H.W., Chu, C.Y., Ho, J.Y., Wu, Y., Cheng, C.H. (2017) IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae. Marine biotechnology (New York, N.Y.). 19(3):310-319

Espín-Palazón, R., Martínez-López, A., Roca, F.J., López-Muñoz, A., Tyrkalska, S.D., Candel, S., García-Moreno, D., Falco, A., Meseguer, J., Estepa, A., Mulero, V. (2016) TNFα Impairs Rhabdoviral Clearance by Inhibiting the Host Autophagic Antiviral Response. PLoS pathogens. 12:e1005699

Liu, X., Cai, X., Zhang, D., Xu, C., Xiao, W. (2016) Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 197(12):4736-4749

Zhang, L., Chen, W.Q., Hu, Y.W., Wu, X.M., Nie, P., Chang, M.X. (2016) TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway. Fish & shellfish immunology. 54:135-43

Chen, H.Y., Liu, W., Wu, S.Y., Chiou, P.P., Li, Y.H., Chen, Y.C., Lin, G.H., Lu, M.W., Wu, J.L. (2015) RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish & shellfish immunology. 43(2):427-35

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Estepa, A., Coll, J. (2015) Innate Multigene Family Memories Are Implicated in the Viral-Survivor Zebrafish Phenotype. PLoS One. 10:e0135483

López-Muñoz, A., Liarte, S., Gómez-González, N.E., Cabas, I., Meseguer, J., García-Ayala, A., Mulero, V. (2015) Estrogen receptor 2b deficiency impairs the antiviral response of zebrafish. Developmental and comparative immunology. 53(1):55-62

Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41

García-Valtanen, P., Martinez-Lopez, A., Ortega-Villaizan, M., Perez, L., Coll, J.M., and Estepa, A. (2014) In addition to its antiviral and immunomodulatory properties, the zebrafish Beta-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Research. 101:136-147

Martinez-Lopez, A., Garcia-Valtanen, P., Ortega-Villaizan, M., Chico, V., Casado, E., Coll, J.M., Estepa, A. (2014) VHSV G glycoprotein major determinants implicated in triggering the host type I IFN antiviral response as DNA vaccine molecular adjuvants. Vaccine. 32(45):6012-9

Sawamiphak, S., Kontarakis, Z., Stainier, D.Y. (2014) Interferon Gamma Signaling Positively Regulates Hematopoietic Stem Cell Emergence. Developmental Cell. 31:640-653

Huang, B., Huang, W.S., and Nie, P. (2013) Characterization of four Mx isoforms in the European eel, Anguilla anguilla. Fish & shellfish immunology. 35(3):1048-54

Galindo-Villegas, J., García-Moreno, D., de Oliveira, S., Meseguer, J., and Mulero, V. (2012) Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proceedings of the National Academy of Sciences of the United States of America. 109(39):E2605-2614

López-Muñoz, A., Sepulcre, M.P., Roca, F.J., Figueras, A., Meseguer, J., and Mulero, V. (2011) Evolutionary conserved pro-inflammatory and antigen presentation functions of zebrafish IFNγ revealed by transcriptomic and functional analysis. Molecular immunology. 48(9-10):1073-1083

Li, Z., Xu, X., Huang, L., Wu, J., Lu, Q., Xiang, Z., Liao, J., Weng, S., Yu, X., and He, J. (2010) Administration of recombinant IFN1 protects zebrafish (Danio rerio) from ISKNV infection. Fish & shellfish immunology. 29(3):399-406

López-Muñoz, A., Roca, F.J., Sepulcre, M.P., Meseguer, J., and Mulero, V. (2010) Zebrafish Larvae Are Unable To Mount a Protective Antiviral Response Against Waterborne Infection by Spring Viremia of Carp Virus. Developmental and comparative immunology. 34(5):546-552

López-Muñoz, A., Roca, F.J., Meseguer, J., and Mulero, V. (2009) New insights into the evolution of IFNs: zebrafish Group II IFNs induce a rapid and transient expression of IFN-dependent genes and display powerful antiviral activities. Journal of immunology (Baltimore, Md. : 1950). 182(6):3440-3449

Sepulcre, M.P., Alcaraz-Pérez, F., López-Muñoz, A., Roca, F.J., Meseguer, J., Cayuela, M.L., and Mulero, V. (2009) Evolution of lipopolysaccharide (LPS) recognition and signaling: fish TLR4 does not recognize LPS and negatively regulates NF-kappaB activation. Journal of immunology (Baltimore, Md. : 1950). 182(4):1836-1845

Roca, F.J., Mulero, I., López-Muñoz, A., Sepulcre, M.P., Renshaw, S.A., Meseguer, J., and Mulero, V. (2008) Evolution of the Inflammatory Response in Vertebrates: Fish TNF-{alpha} Is a Powerful Activator of Endothelial Cells but Hardly Activates Phagocytes. Journal of immunology (Baltimore, Md. : 1950). 181(7):5071-5081

Levraud, J.P., Boudinot, P., Colin, I., Benmansour, A., Peyriéras, N., Herbomel, P., and Lutfalla, G. (2007) Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System. Journal of immunology (Baltimore, Md. : 1950). 178(7):4385-4394

Lo, J., Lee, S., Xu, M., Liu, F., Ruan, H., Eun, A., He, Y., Ma, W., Wang, W., Wen, Z., and Peng, J. (2003) 15,000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Genome research. 13(3):455-466

Lutfalla, G., Roest Crollius, H., Stange-Thomann, N., Jaillon, O., Mogensen, K., and Monneron, D. (2003) Comparative genomic analysis reveals independent expansion of a lineage-specific gene family in vertebrates: The class II cytokine receptors and their ligands in mammals and fish. BMC Genomics. 4(1):29

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Additional Citations (20):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

ZFIN Staff (2015) Data Model Change: Sequence Targeting Reagents Removed from Environment. ZFIN Historical Data.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

UniProt-GOA (2011) Gene Ontology annotation based on the automatic assignment of UniProtKB Subcellular Location terms in UniProtKB/TrEMBL entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

Thisse, B., Thisse, C. (2004) Fast Release Clones: A High Throughput Expression Analysis. ZFIN Direct Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Scientific Curation. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.