ZFIN Morpholino: MO1-pdx1

Target Location

Genome Build: GRCz11Chromosome: 24

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-pdx1

Expressed Gene	Anatomy	Figures
aldh1a3	whole organism	Fig. S6 from Lou et al., 2020
aldh1l2	whole organism	Fig. S6 from Lou et al., 2020
aldh3a1	whole organism	Fig. S6 from Lou et al., 2020
aldh3b1	whole organism	Fig. S6 from Lou et al., 2020
aldh7a1	whole organism	Fig. S6 from Lou et al., 2020

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Phenotype

Phenotype resulting from MO1-pdx1

Phenotype	Fish	Figures
acinar cell decreased amount, abnormal	WT + MO1-pdx1	Fig. 1 from Yee et al., 2001
blood vessel increased branchiness, abnormal	y1Tg + MO1-pdx1 + MO4-tp53	Fig. 2 from Jörgens et al., 2015
blood vessel morphology, abnormal	y1Tg + MO1-pdx1 + MO4-tp53	Fig. 2 from Jörgens et al., 2015
determination of digestive tract left/right asymmetry process quality, abnormal	WT + MO1-pdx1	Fig. 1 from Yee et al., 2001
determination of liver left/right asymmetry process quality, abnormal	WT + MO1-pdx1	Fig. 1 from Yee et al., 2001

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Phenotype of all Fish created by or utilizing MO1-pdx1

Phenotype	Fish	Conditions	Figures
whole organism ins expression decreased amount, abnormal	WT + MO1-pdx1	standard conditions	Fig. 5 from Lou et al., 2020
determination of digestive tract left/right asymmetry process quality, abnormal	WT + MO1-pdx1	standard conditions	Fig. 1 from Yee et al., 2001
pancreatic B cell decreased amount, abnormal	WT + MO1-pdx1	standard conditions	Fig. 1 from Kimmel et al., 2011
determination of liver left/right asymmetry process quality, abnormal	WT + MO1-pdx1	standard conditions	Fig. 1 from Yee et al., 2001
whole organism aldh7a1 expression decreased amount, abnormal	WT + MO1-pdx1	standard conditions	Fig. S6 from Lou et al., 2020

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Citations

Include unpublished citations

Al-Dahmani, Z.M., Li, X., Wiggenhauser, L.M., Ott, H., Kruithof, P.D., Lunev, S., A Batista, F., Luo, Y., Dolga, A.M., Morton, N.M., Groves, M.R., Kroll, J., van Goor, H. (2022) Thiosulfate sulfurtransferase prevents hyperglycemic damage to the zebrafish pronephros in an experimental model for diabetes. Scientific Reports. 12:12077
Wiggenhauser, L.M., Metzger, L., Bennewitz, K., Soleymani, S., Boger, M., Tabler, C.T., Hausser, I., Sticht, C., Wohlfart, P., Volk, N., Heidenreich, E., Buettner, M., Hammes, H.P., Kroll, J. (2022) pdx1 Knockout Leads to a Diabetic Nephropathy-Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage. Diabetes. 71(5):1073-1080
Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723
Wiggenhauser, L.M., Qi, H., Stoll, S.J., Metzger, L., Bennewitz, K., Poschet, G., Krenning, G., Hillebrands, J.L., Hammes, H.P., Kroll, J. (2020) Activation of retinal angiogenesis in hyperglycemic pdx1^-/- zebrafish mutants. Diabetes. 69(5):1020-1031
Schmöhl, F., Peters, V., Schmitt, C.P., Poschet, G., Büttner, M., Li, X., Weigand, T., Poth, T., Volk, N., Morgenstern, J., Fleming, T., Nawroth, P.P., Kroll, J. (2019) CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications. Cellular and molecular life sciences : CMLS. 76(22):4551-4568
Gao, C., Huang, W., Gao, Y., Jan Lo, L., Luo, L., Huang, H., Chen, J., Peng, J. (2018) Zebrafish hhex-null mutant develops an intrahepatic intestinal tube due to de-repression of cdx1b and pdx1. Journal of molecular cell biology. 11(6):448-462
Zhang, Y.M., Zimmer, M.A., Guardia, T., Callahan, S.J., Mondal, C., Di Martino, J., Takagi, T., Fennell, M., Garippa, R., Campbell, N.R., Bravo-Cordero, J.J., White, R.M. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Developmental Cell. 45(5):580-594.e7
She, J., Yuan, Z., Wu, Y., Chen, J., Kroll, J. (2017) Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Molecular metabolism. 8:189-202
O'Hare, E.A., Yerges-Armstrong, L.M., Perry, J.A., Shuldiner, A.R., Zaghloul, N.A. (2016) Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Molecular endocrinology (Baltimore, Md.). 30(4):429-45
Sharma, K.R., Heckler, K., Stoll, S.J., Hillebrands, J.L., Kynast, K., Herpel, E., Porubsky, S., Elger, M., Hadaschik, B., Bieback, K., Hammes, H.P., Nawroth, P.P., Kroll, J. (2016) ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Scientific Reports. 6:37172

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