Gene

pdx1

ID
ZDB-GENE-990415-122
Name
pancreatic and duodenal homeobox 1
Symbol
pdx1 Nomenclature History
Previous Names
  • pdx-1 (1)
  • ipf1 (1)
  • pancreatic and duodenal homeobox gene 1
  • zgc:100874
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of left/right symmetry; endocrine pancreas development; and glucose homeostasis. Predicted to localize to nucleus. Is expressed in several structures, including digestive system; endoderm; intestinal rod; liver primordium; and somite. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1).
Genome Resources
Note
None
Expression
All Expression Data
100 figures from 68 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pdx1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
maturity-onset diabetes of the young type 4 Alliance MODY, type IV 606392
pancreatic agenesis Alliance Pancreatic agenesis 1 260370
type 2 diabetes mellitus Alliance {Diabetes mellitus, type II, susceptibility to} 125853
Associated With pdx1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Domain IPR020479 Homeobox domain, metazoa
Family IPR017995 Homeobox protein, antennapedia type
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox domain, metazoa Homeobox-like domain superfamily Homeobox protein, antennapedia type
UniProtKB:F1RBA3 246
UniProtKB:Q6DC85 246
UniProtKB:O73726 246
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-pdx1 polyclonal Guinea pig
  • IHC
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations