ZFIN Morpholino: MO1-prkcz

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-prkcz

Expressed Gene	Anatomy	Figures
slc20a1a	pronephric proximal convoluted tubule	Fig. 3 from Gerlach et al., 2014
wt1a	pronephric podocyte	Fig. 3 from Gerlach et al., 2014

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Phenotype

Phenotype resulting from MO1-prkcz

Phenotype	Fish	Figures
dorsal longitudinal anastomotic vessel aplastic, abnormal	y1Tg + MO1-prkcz	Fig. 6 from Oubaha et al., 2012
intersegmental vessel has extra parts of type endothelial tip cell filopodium, abnormal	y1Tg + MO1-prkcz	Fig. 6 from Oubaha et al., 2012
intersegmental vessel malformed, abnormal	y1Tg + MO1-prkcz	Fig. 6 from Oubaha et al., 2012
intersegmental vessel endothelial tip cell detached from dorsal aorta, abnormal	y1Tg + MO1-prkcz	Fig. 6 from Oubaha et al., 2012
intersegmental vessel sprouting angiogenesis process quality, abnormal	y1Tg + MO1-prkcz	Fig. 6 from Oubaha et al., 2012

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Phenotype of all Fish created by or utilizing MO1-prkcz

Phenotype	Fish	Conditions	Figures
intersegmental vessel malformed, abnormal	y1Tg + MO1-prkcz	standard conditions	Fig. 6 from Oubaha et al., 2012
dorsal longitudinal anastomotic vessel aplastic, abnormal	y1Tg + MO1-prkcz	standard conditions	Fig. 6 from Oubaha et al., 2012
intersegmental vessel sprouting angiogenesis process quality, abnormal	y1Tg + MO1-prkcz	standard conditions	Fig. 6 from Oubaha et al., 2012
intersegmental vessel endothelial tip cell detached from dorsal aorta, abnormal	y1Tg + MO1-prkcz	standard conditions	Fig. 6 from Oubaha et al., 2012
intersegmental vessel has extra parts of type endothelial tip cell filopodium, abnormal	y1Tg + MO1-prkcz	standard conditions	Fig. 6 from Oubaha et al., 2012

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Citations

Include unpublished citations

Strzyz, P.J., Lee, H.O., Sidhaye, J., Weber, I.P., Leung, L.C., Norden, C. (2015) Interkinetic Nuclear Migration Is Centrosome Independent and Ensures Apical Cell Division to Maintain Tissue Integrity. Developmental Cell. 32(2):203-19
Gerlach, G.F., Wingert, R.A. (2014) Zebrafish pronephros tubulogenesis and epithelial identity maintenance are reliant on the polarity proteins Prkc iota and zeta. Developmental Biology. 396(2):183-200
Krock, B.L., Perkins, B.D. (2014) The Par-PrkC Polarity Complex Is Required for Cilia Growth in Zebrafish Photoreceptors. PLoS One. 9:e104661
Oubaha, M., Lin, M.I., Margaron, Y., Filion, D., Price, E.N., Zon, L.I., Côté, J.F., and Gratton, J.P. (2012) Formation of a PKCzeta/beta-catenin complex in endothelial cells promotes angiopoietin-1-induced collective directional migration and angiogenic sprouting. Blood. 120(16):3371-3381
Grant, P.K., and Moens, C.B. (2010) The neuroepithelial basement membrane serves as a boundary and a substrate for neuron migration in the zebrafish hindbrain. Neural Development. 5:9
Hava, D., Forster, U., Matsuda, M., Cui, S., Link, B.A., Eichhorst, J., Wiesner, B., Chitnis, A., and Abdelilah-Seyfried, S. (2009) Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. Journal of Cell Science. 122(Pt 5):687-695
Baye, L.M., and Link, B.A. (2007) Interkinetic nuclear migration and the selection of neurogenic cell divisions during vertebrate retinogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(38):10143-10152
Cui, S., Otten, C., Rohr, S., Abdelilah-Seyfried, S., and Link, B.A. (2007) Analysis of aPKClambda and aPKCzeta reveals multiple and redundant functions during vertebrate retinogenesis. Molecular and cellular neurosciences. 34(3):431-444

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