ZFIN Image: Zeng et al., 2024, FIGURE 5

Image

Figure Caption

FIGURE 5

Loss of cobll1a leads to abnormal RA metabolism in zebrafish. (A) Line chart of GSEA results with the right ordinate representing the enrichment score. (B) Cluster heat maps of RA metabolism-related genes in DEGs, displaying significant differences between WT and cobll1a mutant. (C) RT-qPCR analysis of the transcriptional expression level of RA metabolism-related genes at 52 hpf cobll1a^−/− compared with WT. (D, F) The expression of aldh1a2 was decreased in cobll1a^−/−embryos, observed in eye and somatic cells at 24 hpf, in liver and intestinal tissues at four dpf. (E) At 4 dpf, the expression of rdh10 was decreased in cobll1a^−/− embryos. (G) At 4 dpf, the expression of cyp26a1 was increased in cobll1a^−/− embryos. (H) At 4dpf, the expression of rbp4 was decreased in cobll1a^−/− embryos.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Cell Dev Biol