Gene

rbp4

ID

ZDB-GENE-000210-19

Name

retinol binding protein 4, plasma

Symbol

rbp4 Nomenclature History

Previous Names

rbp
fb23c12
wu:fb23c12
wu:fb58d04 (1)
wu:fb72b04 (1)
zgc:86911

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable retinol binding activity. Acts upstream of or within liver development and response to retinoic acid. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including apical ectodermal ridge; digestive system; integument; reproductive system; and yolk. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RBP4 (retinol binding protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

26 figures from 13 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu673 (1 image)
eu787 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Li et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rbp4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Microphthalmia/coloboma 10	616428
		Retinal dystrophy, iris coloboma, and comedogenic acne syndrome	615147

Associated With rbp4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR022272	Lipocalin family conserved site
Domain	IPR000566	Lipocalin/cytosolic fatty-acid binding domain
Family	IPR002449	Retinol binding protein/Purpurin
Family	IPR022271	Lipocalin, ApoD type
Homologous_superfamily	IPR012674	Calycin

Domain Details Per Protein

Protein	Length	Calycin	Lipocalin, ApoD type	Lipocalin/cytosolic fatty-acid binding domain	Lipocalin family conserved site	Retinol binding protein/Purpurin
UniProtKB:Q9PT95 InterPro	192

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rbp4-202 (1) Ensembl	Ensembl	574 nt	Select Tool ZFIN BLAST
mRNA	rbp4-203 (1) Ensembl	Ensembl	1,044 nt	Select Tool ZFIN BLAST
ncRNA	rbp4-003 (1) Ensembl	Ensembl	850 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations