Gene

rarab

ID
ZDB-GENE-980526-72
Name
retinoic acid receptor, alpha b
Symbol
rarab Nomenclature History
Previous Names
  • rara2b (1)
  • fj66e06
  • NR1B1-B (1)
  • nr1b1b (1)
  • RARalpha-B (1)
  • wu:fj66e06
  • zRAR-alpha-2.B
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and pectoral fin development. Acts upstream of or within liver development; midbrain-hindbrain boundary development; and secondary heart field specification. Predicted to be located in nucleus. Is expressed in several structures, including endoderm; hindbrain neural keel; mesoderm; nervous system; and neural plate. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia; lung carcinoma (multiple); and syndromic microphthalmia 12. Orthologous to several human genes including RARA (retinoic acid receptor alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
37 figures from 12 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rarab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute promyelocytic leukemia Alliance Leukemia, acute promyelocytic 612376
Associated With rarab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003078 Retinoic acid receptor
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Retinoic acid receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:E7EZ95 460
UniProtKB:Q7ZTI3 458
UniProtKB:A0A2R8Q393 452
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-rarab monoclonal Mouse
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations