Gene
stra6
- ID
- ZDB-GENE-060616-252
- Name
- signaling receptor and transporter of retinol STRA6
- Symbol
- stra6 Nomenclature History
- Previous Names
-
- im:7151282
- wu:fc51h06
- zgc:136689 (1)
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Enables calmodulin binding activity; identical protein binding activity; and molecular adaptor activity. Acts upstream of or within chordate embryonic development and retinol transport. Located in plasma membrane. Is expressed in several structures, including hindbrain neural plate; immature eye; nervous system; pleuroperitoneal region; and trunk. Used to study syndromic microphthalmia 9. Human ortholog(s) of this gene implicated in syndromic microphthalmia 9. Orthologous to human STRA6 (signaling receptor and transporter of retinol STRA6).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 14 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151282 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Isken et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-stra6 | N/A | Isken et al., 2008 |
| MO2-stra6 | N/A | (2) |
| MO3-stra6 | N/A | Isken et al., 2008 |
| MO4-stra6 | N/A | Melvin et al., 2013 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndromic microphthalmia 9 | Alliance | Microphthalmia, isolated, with coloboma 8 | 601186 |
| syndromic microphthalmia 9 | Alliance | Microphthalmia, syndromic 9 | 601186 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026612 | Receptor for retinol uptake STRA6-like |
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Domain Details Per Protein
| Protein | Length | Receptor for retinol uptake STRA6-like |
|---|---|---|
|
UniProtKB:A0A8M9PGX1
|
670 | |
|
UniProtKB:F1RAX4
|
670 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-4M3 | ZFIN Curated Data | |
| Encodes | EST | fc51h06 | ||
| Encodes | EST | IMAGE:7151282 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:136689 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162541 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045312 (1) | 2913 nt | ||
| Genomic | GenBank:AL929050 (1) | 196743 nt | ||
| Polypeptide | UniProtKB:A0A8M9PGX1 (1) | 670 aa |
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
- Valenzuela, L., Pacheco, S., Rincón, G., Pavez, L., Lam, N., Hernández, A.J., Dantagnan, P., González, F., Jilberto, F., Ravanal, M.C., Ramos, C., Garcia, H., Araneda, C., Ulloa, P.E. (2021) Intestinal Transcriptome Analysis Reveals Enrichment of Genes Associated with Immune and Lipid Mechanisms, Favoring Soybean Meal Tolerance in High-Growth Zebrafish (Danio Rerio). Genes. 12(5):
- Young, B.D., Varney, K.M., Wilder, P.T., Costabile, B.K., Pozharski, E., Cook, M.E., Godoy-Ruiz, R., Clarke, O.B., Mancia, F., Weber, D.J. (2021) Physiologically Relevant Free Ca2+ Ion Concentrations Regulate STRA6-Calmodulin Complex Formation via the BP2 Region of STRA6. Journal of molecular biology. 433:167272
- Solanki, A.K., Kondkar, A.A., Fogerty, J., Su, Y., Kim, S.H., Lipschutz, J.H., Nihalani, D., Perkins, B.D., Lobo, G.P. (2020) A Functional Binding Domain in the Rbpr2 Receptor Is Required for Vitamin A Transport, Ocular Retinoid Homeostasis, and Photoreceptor Cell Survival in Zebrafish. Cells. 9(5):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Shi, Y., Obert, E., Rahman, B., Rohrer, B., Lobo, G.P. (2017) The Retinol Binding Protein Receptor 2 (Rbpr2) is required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish. Scientific Reports. 7:16207
- Tzima, E., Serifi, I., Tsikari, I., Alzualde, A., Leonardos, I., Papamarcaki, T. (2017) Transcriptional and Behavioral Responses of Zebrafish Larvae to Microcystin-LR Exposure. International Journal of Molecular Sciences. 18(2)
- Chen, Y., Clarke, O.B., Kim, J., Stowe, S., Kim, Y.K., Assur, Z., Cavalier, M., Godoy-Ruiz, R., von Alpen, D.C., Manzini, C., Blaner, W.S., Frank, J., Quadro, L., Weber, D.J., Shapiro, L., Hendrickson, W.A., Mancia, F. (2016) Structure of the STRA6 receptor for retinol uptake. Science (New York, N.Y.). 353(6302)
- Pradhan, A., Olsson, P.E. (2015) Inhibition of retinoic acid synthesis disrupts spermatogenesis and fecundity in zebrafish. General and comparative endocrinology. 217-218:81-91
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