Gene
raraa
- ID
- ZDB-GENE-980526-284
- Name
- retinoic acid receptor, alpha a
- Symbol
- raraa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables nuclear receptor activity. Involved in hindbrain morphogenesis and response to retinoic acid. Acts upstream of or within liver development. Predicted to be located in nucleus. Is expressed in several structures, including endoderm; gonad; mesoderm; nervous system; and neural keel. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human RARA (retinoic acid receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 41 figures from 17 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- s74155 (28 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Garnaas et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| acute promyelocytic leukemia | Alliance | Leukemia, acute promyelocytic | 612376 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Domain | IPR047158 | Retinoic acid receptor, ligand-binding domain |
| Domain | IPR047159 | Retinoic acid receptor, DNA-binding domain |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003078 | Retinoic acid receptor |
| Homologous_superfamily | IPR013088 | Zinc finger, NHR/GATA-type |
| Homologous_superfamily | IPR035500 | Nuclear hormone receptor-like domain superfamily |
Domain Details Per Protein
| Protein | Length | Nuclear hormone receptor | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Retinoic acid receptor | Retinoic acid receptor, DNA-binding domain | Retinoic acid receptor, ligand-binding domain | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q90271
|
444 | ||||||||
|
UniProtKB:T2DKU4
|
447 |
Interactions and Pathways
Plasmids
No data available