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Figure 5

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ZDB-IMAGE-230330-23
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Figures for Sobah et al., 2023
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Figure 5

Effect of socs3b ablation on the innate immune cell response to injury. Wildtype (WT, socs3bwt/wt) and knockout (KO, socs3bmdu24/mdu24) embryos on either the Tg(mpx::GFP) or Tg(mpeg1.1::GFP) transgenic background were subjected to a tail wounding assay at 5 dpf and imaged under fluorescence from 0-24 hours post wounding (hpw) (A). Representative images of mpx+ neutrophil (B) and mpeg1.1+ macrophage (E) cell migration to the injury site (dotted line) at the indicated times, with scale bars representing 100 mm. Quantitation of all migrating mpx+(C) and normalized to total mpx+ cells (D) as well as all mpeg1.1+ cells (F). Gene expression analysis of the indicated genes in WT and KO embryos subjected to wounding presented as fold-change (log2) relative to 0 hpw (G). Panels (C, D, F and G) show means and SEM, with statistical significance indicated using unpaired t tests (C, D and F) or one-way ANOVA (G) (*** p < 0.001, ** p < 0.01, * p < 0.05, n = 8-12).

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