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Sobah et al., 2023 - Socs3b regulates the development and function of innate immune cells in zebrafish

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Figure 5

Effect of socs3b ablation on the innate immune cell response to injury. Wildtype (WT, socs3b^wt/wt) and knockout (KO, socs3b^mdu24/mdu24) embryos on either the Tg(mpx::GFP) or Tg(mpeg1.1::GFP) transgenic background were subjected to a tail wounding assay at 5 dpf and imaged under fluorescence from 0-24 hours post wounding (hpw) (A). Representative images of mpx⁺ neutrophil (B) and mpeg1.1⁺ macrophage (E) cell migration to the injury site (dotted line) at the indicated times, with scale bars representing 100 mm. Quantitation of all migrating mpx⁺(C) and normalized to total mpx⁺ cells (D) as well as all mpeg1.1⁺ cells (F). Gene expression analysis of the indicated genes in WT and KO embryos subjected to wounding presented as fold-change (log₂) relative to 0 hpw (G). Panels (C, D, F and G) show means and SEM, with statistical significance indicated using unpaired t tests (C, D and F) or one-way ANOVA (G) (*** p < 0.001, ** p < 0.01, * p < 0.05, n = 8-12).

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol