Gene

ccr2

ID
ZDB-GENE-151216-1
Name
chemokine (C-C motif) receptor 2
Symbol
ccr2 Nomenclature History
Previous Names
  • si:ch211-207g17.2
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have chemokine receptor activity. Involved in monocyte activation. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); diabetes mellitus (multiple); eye disease (multiple); and rheumatoid arthritis (multiple). Orthologous to several human genes including CCR2 (C-C motif chemokine receptor 2); CCR4 (C-C motif chemokine receptor 4); and CCR5 (C-C motif chemokine receptor 5 (gene/pseudogene)).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ccr2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 12 Alliance {Macular degeneration, age-related, 12} 613784
coronary artery disease Alliance {Coronary artery disease, resistance to} 607339
type 1 diabetes mellitus 22 Alliance {Diabetes mellitus, insulin-dependent, 22} 612522
{Hepatitis C virus, resistance to} 609532
{HIV infection, susceptibility/resistance to}
{Rapid progression to AIDS from HIV1 infection} 609423
{West nile virus, susceptibility to} 610379
Associated With ccr2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000355 Chemokine receptor family
Domain Details Per Protein
Protein Length Chemokine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:F1QYD4 358
UniProtKB:A0A140LFQ7 354
UniProtKB:A0A140LFN4 360
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations