Gene
ccr2
- ID
- ZDB-GENE-151216-1
- Name
- chemokine (C-C motif) receptor 2
- Symbol
- ccr2 Nomenclature History
- Previous Names
-
- ccr5 (1)
- si:ch211-207g17.2
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to have C-C chemokine binding activity and C-C chemokine receptor activity. Involved in monocyte activation. Predicted to localize to external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and sarcoidosis (multiple). Orthologous to several human genes including CCR2 (C-C motif chemokine receptor 2); CCR4 (C-C motif chemokine receptor 4); and CCR5 (C-C motif chemokine receptor 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| age related macular degeneration 12 | Alliance | {Macular degeneration, age-related, 12} | 613784 |
| coronary artery disease | Alliance | {Coronary artery disease, resistance to} | 607339 |
| type 1 diabetes mellitus 22 | Alliance | {Diabetes mellitus, insulin-dependent, 22} | 612522 |
| Polycystic lung disease | 219600 | ||
| {Hepatitis C virus, resistance to} | 609532 | ||
| {HIV infection, susceptibility/resistance to} | 609423 | ||
| {Rapid progression to AIDS from HIV1 infection} | 609423 | ||
| {West nile virus, susceptibility to} | 610379 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Chemokine receptor family | GPCR, rhodopsin-like, 7TM | G-protein coupled receptor 1 | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:A0A140LFQ7
|
354 | ||||
|
UniProtKB:F1QYD4
|
358 |
Interactions and Pathways
No data available
Plasmids
No data available